We disclosed herein a straightforward strategy for the synthesis of unprecedented -((trifluoromethyl)thio), -(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074438 | PMC |
| http://dx.doi.org/10.1039/d2sc06542h | DOI Listing |
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