Although small cell neuroendocrine carcinoma of the ureter (ureteral SCNEC) is rare, it always leads to a poor prognosis. Also, no treatment recommendation has been given for ureteral SCNEC, with only PD-1/PD-L1 inhibitors being used for its treatment. Here, we report a case of atypical symptoms of cardiac infarction caused by a PD-1 inhibitor used in the treatment of ureteral SCNEC and hope to address concerns regarding the possible cardiac toxicity caused by PD-1/PD-L1 inhibitors in ureteral SCNEC patients.
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http://dx.doi.org/10.3389/fonc.2023.1114397 | DOI Listing |
Front Oncol
May 2024
Department of Pathology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Int J Surg Case Rep
October 2023
Department of Pathology Anatomy, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Dr. Soetomo General-Academic Hospital, Surabaya, East Java, Indonesia.
Introduction And Importance: Primary small cell neuroendocrine carcinoma (SCNEC) in the urinary tract represents less than 0.5 % of urinary tract cancers, and bladder or prostate are the most common sites. Early diagnosis and treatment of ureteral SCNECs are challenging due to nonspecific clinical symptoms and radiographic findings.
View Article and Find Full Text PDFFront Oncol
March 2023
Department of Oncology, the People's Hospital of Yubei District of Chongqing City, Chongqing, China.
Although small cell neuroendocrine carcinoma of the ureter (ureteral SCNEC) is rare, it always leads to a poor prognosis. Also, no treatment recommendation has been given for ureteral SCNEC, with only PD-1/PD-L1 inhibitors being used for its treatment. Here, we report a case of atypical symptoms of cardiac infarction caused by a PD-1 inhibitor used in the treatment of ureteral SCNEC and hope to address concerns regarding the possible cardiac toxicity caused by PD-1/PD-L1 inhibitors in ureteral SCNEC patients.
View Article and Find Full Text PDFClin Case Rep
January 2023
Department of Ultrasound, Affiliated Dongguan Hospital Southern Medical University, Dongguan People's Hospital Dongguan China.
Small cell neuroendocrine carcinoma (SCNEC) of the ureter is a rare malignant tumor originating from the metaplasia of urothelial cells. This report presents a case of ureteral SCNEC that was preliminarily disclosed by computed tomography; thereafter, transabdominal ultrasonography, transrectal ultrasonography, and magnetic resonance urography were performed to characterize the mass.
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August 2021
Department of Radiation Oncology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Background: Primary small cell neuroendocrine carcinoma (SCNEC) in the ureter is extremely rare and has been sporadically reported in case reports. Its incidence, diagnosis, treatment, and outcomes have not yet been thoroughly understood. Here we present a patient with advanced SCNEC in the ureter who was treated by multimodal strategies.
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