The notion of genre has been widely explored using quantitative methods from both lexical and syntactical perspectives. However, discourse structure has rarely been used to examine genre. Mostly concerned with the interrelation of discourse units, discourse structure can play a crucial role in genre analysis. Nevertheless, few quantitative studies have explored genre distinctions from a discourse structure perspective. Here, we use two English discourse corpora (RST-DT and GUM) to investigate discourse structure from a novel viewpoint. The RST-DT is divided into four small subcorpora distinguished according to genre, and another corpus (GUM) containing seven genres are used for cross-verification. An RST (rhetorical structure theory) tree is converted into dependency representations by taking information from RST annotations to calculate the through a process similar to that used to calculate syntactic dependency distance. Moreover, the data on dependency representations deriving from the two corpora are readily convertible into network data. Afterwards, we examine different genres in the two corpora by combining discourse distance and discourse network. The two methods are mutually complementary in comprehensively revealing the distinctiveness of various genres. Accordingly, we propose an effective quantitative method for assessing genre differences using discourse distance and discourse network. This quantitative study can help us better understand the nature of genre.
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http://dx.doi.org/10.1515/cllt-2020-0064 | DOI Listing |
J Med Chem
January 2025
Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu 610041, China.
Molecular mechanisms of chaperone-mediated autophagy (CMA) constitute essential regulatory elements in cellular homeostasis, encompassing protein quality control, metabolic regulation, cellular signaling cascades, and immunological functions. Perturbations in CMA functionality have been causally associated with various pathological conditions, including neurodegenerative pathologies and neoplastic diseases. Recent advances in targeted protein degradation (TPD) methodologies have demonstrated that engineered degraders incorporating KFERQ-like motifs can facilitate lysosomal translocation and subsequent proteolysis of noncanonical substrates, offering novel therapeutic interventions for both oncological and neurodegenerative disorders.
View Article and Find Full Text PDFThis paper examines the geopolitical implications of knowledge production in psychology through two studies that respond to the growing body of work on the 'Decolonisation of Knowledge' and the 'Decolonisation of Psychology' over the past two decades. By adopting a constructivist approach, particularly through the lens of Social Representation Theory (SRT), these studies explore the ways in which geopolitical contexts shape decolonial activism within psychological and scientific discourse. The first study sheds light on the lexical divergences in the construction of knowledge within the domains of psychology.
View Article and Find Full Text PDFMed Educ
January 2025
The Institute for Education Research, University Health Network, Toronto, Canada.
Introduction: Intraprofessional collaboration between family physicians (FPs) and specialist physicians (SPs) is posited to improve patient outcomes but is hindered by power dynamics. Research informing intraprofessional training on hospital wards often conceptualizes power at an interactional level. However, less is known about how social structures make these power dynamics possible.
View Article and Find Full Text PDFJ Educ Health Promot
November 2024
Rocky Mountain Prevention Research Center, Colorado School of Public Health, University of Colorado, Aurora, CO, United States.
Background: Early childhood education (ECE) caregivers experience high levels of stress and increased physical and emotional work demands. Promoting mindfulness practices may be an acceptable and feasible strategy to bolster mental health and well-being. The present study's goals were to explore the 1) perceptions and 2) cultural differences surrounding mindfulness practices and mental health among Spanish-speaking Hispanic (SSH), English-speaking Hispanic (ESH), and English-speaking non-Hispanic (ESNH) informal ECE caregivers.
View Article and Find Full Text PDFActa Pharm Sin B
December 2024
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding a viable resolution to the formidable barriers presented by the cutaneous interface. This review examines MNs as an advanced approach to enhancing dermatological pathology management. It explores the complex dermis structure and highlights the limitations of traditional transdermal methods, emphasizing MNs' advantage in bypassing the stratum corneum to deliver drugs directly to the subdermal matrix.
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