The chronology and dynamics of the female germ cell development, of the mitotic activity of oogonia, and of the chromosome rearrangements at prophase I of meiosis have been quantitatively estimated in 30 cow embryos and foetuses at the age of 1.5 to 9 months. The sexual differentiation of the gonads was shown in a 1.5 month old embryo. The oocytes at the stages of preleptotene chromosome condensation and decondensation occurred in the 1.5 month old embryos and their maximum number was observed in the 2-5 month old foetuses. The leptotene oocytes were found in the 2-2.5 month old foetuses. The transition to zygotene and pachytene was also recorded in the 2-2.5 month old foetuses but their maximum number was observed in the 4-6 month old foetuses; their number was reduced to single oocytes thereafter. The first diplotene oocytes appeared in the 3 month old foetuses but the active transition of the oocytes to diplotene was observed after four months of development. The formation of a layer of follicle cells takes place around the diplotene oocytes. The vast majority of degenerating germ cells are the oocytes in zygotene-pachytene and in diplotene. The population of germ cells is formed by the mitotic division of oogonia in the cow foetuses, mainly at the age of 1.5 to 4 months of development.
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J Int Med Res
December 2024
Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, China.
Objective: This study aimed to analyse the causes of foetal mild-to-moderate isolated ventriculomegaly (IVM) and to evaluate the prognosis of neurological development in surviving children in different subgroups.
Methods: We retrospectively studied mild-to-moderate IVM diagnosed by prenatal ultrasound scans in different subgroups according to the laterality of IVM, the degree of IVM and foetal sex independently. The results of foetal chromosomal microarray analysis, virological tests of umbilical cord blood or amniotic fluid, foetal magnetic resonance imaging and ultrasound were collected.
J Gynecol Obstet Hum Reprod
December 2024
URP FETUS 7328, Federation for Research into Innovative Explorations and Therapeutics in Utero, and LUMIERE Platform, University of Paris Cité, Paris, France; Department of Obstetrics and Gynecology, Pitié-Salpêtrière Hospital, APHP, Sorbonne University, Paris, France. Electronic address:
Background: Achondroplasia, due to a specific pathogenic variant in FGFR3, is the most common viable skeletal dysplasia and the diagnosis is mostly done in the prenatal period. Since 2021, the use of Vosoritide, a specific treatment for achondroplasia, validated in phase 3 placebo-controlled trials, has been recommended to significantly increase the height of children and infants. In the light of these new therapeutic prospects, a complete understanding of the pathophysiology of skeletal damages occurring from foetal life is required.
View Article and Find Full Text PDFHum Reprod
October 2024
Amsterdam Reproduction & Development Research Institute, Amsterdam UMC, Amsterdam, The Netherlands.
Study Question: Does preconceptional exposure to oil-based iodinated contrast media during hysterosalpingography (HSG) impact children's neurodevelopment compared with exposure to water-based alternatives?
Summary Answer: Our study found no large-sized effects for neurodevelopment in children with preconceptional exposure to oil-based iodinated contrast media during HSG compared with water-based alternatives.
What Is Known Already: HSG is widely used as a diagnostic tool in the female fertility work-up. Tubal flushing with oil-based iodinated contrast has been shown to enhance fertility outcomes in couples with unexplained infertility, increasing the chances of pregnancy and live birth compared with water-based alternatives.
BJOG
December 2024
Department of Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Objective: Pregnancy complicated with type B aortic dissection is a rare but devastating condition. Guidelines for managing this condition are lacking. We present our observation and experiences in managing five pregnant women with complicated type B aortic dissection in the second or third trimesters, aiming to gain insights that can aid in proposing an appropriate management strategy.
View Article and Find Full Text PDFJ Clin Med
March 2024
Internal Medicine, Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Civico, 90127 Palermo, Italy.
During pregnancy and in the post-partum period, several diseases may arise or become exacerbated. Acute pancreatitis is an inflammatory disease with an increasing incidence in Western countries. The incidence of acute pancreatitis during pregnancy is not different with respect to the general population, but this incidence increases in the first 2 years after delivery.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!