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Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial. | LitMetric
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Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial.

Angela R Branche Nadine G Rouphael Cecilia Losada Lindsey R Baden Evan J Anderson Anne F Luetkemeyer David J Diemert Patricia L Winokur Rachel M Presti Angelica C Kottkamp Ann R Falsey Sharon E Frey Richard Rupp Martín Bäcker Richard M Novak Emmanuel B Walter Lisa A Jackson Susan J Little Lilly C Immergluck Siham M Mahgoub

medRxiv

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Published: March 2023

In a randomized clinical trial, we compare early neutralizing antibody responses after boosting with bivalent SARS-CoV-2 mRNA vaccines based on either BA.1 or BA.4/BA.5 Omicron spike protein combined with wildtype spike. Responses against SARS-CoV-2 variants exhibited the greatest reduction in titers against currently circulating Omicron subvariants for both bivalent vaccines.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081431PMC
http://dx.doi.org/10.1101/2023.01.31.23285306DOI Listing

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