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A mouse model of deep vein thrombosis by inferior vena cava hypoperfusion using ameroid constrictors.
Sci Rep
January 2025
Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Traditional mouse models for deep vein thrombosis (DVT), frequently utilized in research focused on cancer-associated thrombosis (CAT), reliably induce thrombus formation by obstructing blood flow (BF) in the inferior vena cava (IVC), which does not occur in humans. Therefore, to develop a new DVT model for CAT studies, we implanted an ameroid constrictor (AC), a hygroscopic casein C-shape device, around the IVC and aorta of immunocompromised mice. We evaluated the thrombus 3 and 8 days post-AC implantation and compared it with the traditional model 2 days post-vena cava ligation.
View Article and Find Full Text PDFDMEK Surgical Strategy in Aphakic and Vitrectomized Eyes.
Eur J Ophthalmol
January 2025
Cornea and Refractive Surgery Unit, Instituto de Microcirugía Ocular (IMO), Barcelona, 08035, Spain.
Article Synopsis
- After 15 years of DMEK experience, the technique has shown high success rates but still struggles with certain eye conditions like aphakia and eyes that have had vitrectomy.
- A new method involves injecting an air bubble under the Descemet membrane graft to help unroll it more efficiently during surgery.
- This approach has been found to decrease surgical time while ensuring successful attachment of the graft, offering a promising option for complex DMEK cases.
Navigating antibiotic therapy in acute cholangitis: Best practices and new insights.
J Hepatobiliary Pancreat Sci
November 2024
Department of Gastroenterology, Medicine Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Article Synopsis
- Antibiotic resistance globally causes increased health issues, costs, and mortality, highlighting the need for better antibiotic usage research, especially for treating acute cholangitis (AC), which often requires antimicrobial therapy.
- The Tokyo Guidelines 2018 suggest 4-7 days of antibiotics after biliary drainage, but this recommendation lacks strong evidence and is mainly based on expert opinions.
- Recent studies propose a shorter 1-3 day antibiotic treatment, prompting a reevaluation of treatment duration to improve effectiveness while minimizing resistance and side effects, taking into account local resistance patterns and patient-specific risks.
Assessing Quality of Ultrasound Attenuation Coefficient Results for Liver Fat Quantification.
Diagnostics (Basel)
September 2024
SOD Medicina Interna ed Epatologia, Azienda Ospedaliera Universitaria Careggi, 50134 Florence, Italy.
Background/objectives: Algorithms for quantifying liver fat content based on the ultrasound attenuation coefficient (AC) are currently available; however, little is known about whether their accuracy increases by applying quality criteria such as the interquartile range-to-median ratio (IQR/M) or whether the median or average AC value should be used.
Methods: AC measurements were performed with the Aplio i800 ultrasound system using the attenuation imaging (ATI) algorithm (Canon Medical Systems, Otawara, Tochigi, Japan). Magnetic resonance imaging proton density fat fraction (MRI-PDFF) was the reference standard.
SNX27:Retromer:ESCPE-1-mediated early endosomal tubulation impacts cytomegalovirus replication.
Front Cell Infect Microbiol
October 2024
Department of Physiology, Immunology and Pathophysiology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Introduction: Cytomegaloviruses (CMVs) extensively reorganize the membrane system of the cell and establish a new structure as large as the cell nucleus called the assembly compartment (AC). Our previous studies on murine CMV (MCMV)-infected fibroblasts indicated that the inner part of the AC contains rearranged early endosomes, recycling endosomes, endosomal recycling compartments and trans-Golgi membrane structures that are extensively tubulated, including the expansion and retention of tubular Rab10 elements. An essential process that initiates Rab10-associated tubulation is cargo sorting and retrieval mediated by SNX27, Retromer, and ESCPE-1 (endosomal SNX-BAR sorting complex for promoting exit 1) complexes.
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