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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079883 | PMC |
| http://dx.doi.org/10.3389/fbioe.2023.1170933 | DOI Listing |
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Call for Reforms in the NEET-UG Examination (National Eligibility cum Entrance Test - Undergraduate): Addressing Human Resources in Health for India, the World's Most Populous Country.
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Founder and Chairman Emeritus, Academy of Family Physicians of India, New Delhi, India.
The National Eligibility cum Entrance Test for Undergraduate (NEET-UG) in India serves as a unified admission examination for undergraduate medical courses, aiming to standardize assessment across diverse educational backgrounds. Despite its goals, NEET-UG has faced criticism over fairness, excessive reliance on coaching, and its impact on students' holistic development. The article reviews the limitations of the current NEET-UG format and proposes reforms, emphasizing the need to align the syllabus more closely with medical requirements by reducing physics and chemistry content and prioritizing biology.
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Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinoma.
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Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Immune checkpoint inhibitors can lead to 'exceptional', durable responses in a subset of persons. However, the molecular basis of exceptional response (ER) to immunotherapy in metastatic clear cell renal cell carcinoma (mccRCC) has not been well characterized. Here we analyzed pretherapy genomic and transcriptomic data in treatment-naive persons with mccRCC treated with standard-of-care immunotherapies: (1) combination of programmed cell death protein and ligand 1 (PD1/PDL1) and cytotoxic T lymphocyte-associated protein 4 inhibitors (IO/IO) or (2) combination of PD1/PDL1 and vascular endothelial growth factor (VEGF) receptor inhibitors (IO/VEGF).
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