AI Article Synopsis
- The Wnt/β-catenin signaling pathway is crucial for maintaining heart development and tissue health, primarily by regulating β-catenin stability and localization.
- Recent studies link disruptions in this pathway to various cardiac diseases, including heart attacks and arrhythmias, highlighting a growing healthcare concern.
- The review discusses the importance of understanding β-catenin's role in these conditions and explores potential inhibitors that could lead to new treatments for cardiac diseases.
Article Abstract
The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability and nuclear localization of β-catenin and plays an important role in adult heart development and cardiac tissue homeostasis. In recent years, an increasing number of researchers have implicated the dysregulation of this signaling pathway in a variety of cardiac diseases, such as myocardial infarction, arrhythmias, arrhythmogenic cardiomyopathy, diabetic cardiomyopathies, and myocardial hypertrophy. The morbidity and mortality of cardiac diseases are increasing, which brings great challenges to clinical treatment and seriously affects patient health. Thus, understanding the biological roles of the Wnt/β-catenin pathway in these diseases may be essential for cardiac disease treatment and diagnosis to improve patient quality of life. In this review, we summarize current research on the roles of β-catenin in human cardiac diseases and potential inhibitors of Wnt/β-catenin, which may provide new strategies for cardiac disease therapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073558 | PMC |
| http://dx.doi.org/10.3389/fphar.2023.1157043 | DOI Listing |
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