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Blastomycosis is a rare endemic fungal infection caused by the dimorphic fungus It is more likely to occur in persons living in areas of the United States and Canada, which border the Ohio and Mississippi River Valleys and the Great Lakes region. Most infections are localized to the lungs, often presenting as acute or chronic pneumonia. Occasionally, patients progress to develop disseminated disease and extrapulmonary infections. Blastomycosis tends to be misdiagnosed initially at clinical evaluation as it is rare and may resemble other common conditions. We present a case of a 78-year-old immunosuppressed renal transplant patient who was suspected of having gout but eventually was diagnosed with an unusual presentation of septic arthritis of the ankle secondary to blastomycosis.
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http://dx.doi.org/10.1177/23247096231166674 | DOI Listing |
J Invest Dermatol
February 2025
Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:
Topical steroid withdrawal (TSW) is a controversial diagnosis advocated by patients but often confused for atopic dermatitis. We conducted a multimodal pilot study of 16 patients fitting the TSW diagnostic profile, contrasting them against patients with atopic dermatitis (n = 10) and healthy controls (n = 11). Our clinical evaluations established objective diagnostic criteria that distinguish TSW from atopic dermatitis, metabolomics and transcriptomics of skin biopsies suggested that neuroinflammatory pathways are associated with complex I-mediated oxidation of NAD+, cellular and mouse models demonstrated that NAD+ metabolism was proinflammatory and glucocorticoid responsive, whereas functional assays demonstrated that the metabolic effects of glucocorticoids on the only cell type that aligns with the distribution and duration of TSW pathology could be mitigated by complex I blockade.
View Article and Find Full Text PDFJBJS Case Connect
January 2025
Department of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Case: A 26-month-old child with spastic quadriplegic cerebral palsy, TPN dependence, laryngomalacia, and G6PD deficiency presented with right hip pain with no known recent trauma. Imaging revealed a slipped capital femoral epiphysis (SCFE). The patient underwent hip irrigation and debridement for potential septic arthritis, with SCFE stabilized using buried 2.
View Article and Find Full Text PDFFront Ophthalmol (Lausanne)
February 2025
Ophthalmology Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
Background: Secukinumab is a monoclonal antibody that selectively neutralizes interleukin-17A and has shown efficacy in the treatment of psoriatic arthritis, psoriasis, and axial spondyloarthritis. Its use in non-anterior non-infectious uveitis is controversial, with evidence generally not supporting its effectiveness in these conditions. However, the role of secukinumab in anterior non-infectious uveitis remains unclear.
View Article and Find Full Text PDFClin Shoulder Elb
March 2025
Department of Orthopedic Surgery, Yeungnam University College of Medicine, Daegu, Korea.
Background: This study sought to evaluate the effectiveness of a combined treatment approach for septic shoulder arthritis involving arthroscopic synovectomy and use of antibiotic-impregnated polymethylmethacrylate (PMMA) beads for localized antibiotic delivery.
Methods: This retrospective study included 22 patients with septic shoulder arthritis treated at our institution between 2017 and 2023. The treatment involved arthroscopic lavage, debridement, and insertion of antibiotic-impregnated PMMA beads.
Diagnostics (Basel)
March 2025
Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX 77030, USA.
Oculomics is an emerging field that leverages ophthalmic imaging data to identify biomarkers of systemic disease, facilitating early diagnosis and risk stratification. Despite its growing recognition, gaps remain in the literature regarding the clinical applications of oculomics. Various systemic diseases-including metabolic disorders (e.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!