Ruminant Metabolic Diseases: Perturbed Homeorhesis.

The 6-week period encompassing parturition, termed the transition period, is recognized as the most fragile period in the life cycle of the ruminant animal. The period accounts for the greatest risk of health events that can adversely affect animal health, lactational performance, and future reproductive success. Critical endocrine and metabolic adaptations take place in allowing the animal to change nutrient priorities from supporting pregnancy to sustaining lactation. A reductionist perspective of underlying pathogenesis provided minimal metabolic disease prevalence improvement. Recent research has recognized metabolic regulatory complexity and role for activated inflammatory response underpinning dysregulation of homeorhesis during transition.