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Revisiting immune checkpoint inhibitors: new strategies to enhance efficacy and reduce toxicity.
Front Immunol
December 2024
Medical Education Department, Guangdong Provincial People's Hospital, Zhuhai Hospital (Jinwan Central Hospital of Zhuhai), Zhuhai, China.
Pediatric endoscopic sinus surgery: Revisited 35 years later.
Am J Otolaryngol
December 2024
Department of Otolaryngology - Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, United States of America.
Over the past 35 years, pediatric endoscopic sinus surgery (PESS) has significantly evolved from its inception as a novel intervention to become a cornerstone in the management of pediatric sinus disorders. This evolution is reflective of a broader shift towards a more nuanced understanding and treatment of pediatric chronic rhinosinusitis (PCRS), marked by the introduction of comprehensive guidelines and the refinement of surgical indications. Recent literature and the extensive experience of the senior author, who has been at the forefront of utilizing PESS since its inception, highlight a noticeable shift in the procedure's utilization.
View Article and Find Full Text PDFRevisit to Endolymphatic Duct Identification Using Middle Cranial Fossa Dural Plate: A Novel Technique.
Cureus
November 2024
Otolaryngology - Head and Neck Surgery, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND.
Objectives: Surgical treatments for Ménière's disease differ in efficacy. Endolymphatic duct blockage (EDB) is favored for its minimal risk and ability to preserve hearing. One of the main challenges in the technique is the difficulty in accurately identifying the endolymphatic duct (ED).
View Article and Find Full Text PDFDevelopment and Usability of an Advance Care Planning Website (My Voice) to Empower Patients With Heart Failure and Their Caregivers: Mixed Methods Study.
JMIR Aging
December 2024
Cancer Prevention and Control, Duke Cancer Institute, Durham, NC, United States.
Background: Web-based advance care planning (ACP) interventions offer a promising solution to improve ACP engagement, but none are specifically designed to meet the needs of patients with heart failure and their caregivers.
Objective: We aimed to develop and assess the usability and acceptability of a web-based ACP decision aid called "My Voice," which is tailored for patients with heart failure and their caregivers.
Methods: This study's team and advisory board codeveloped the content for both patient and caregiver modules in "My Voice.
Microbial biomass stoichiometry and proportion of Fe organic complexes separately shape the heterogeneity of mixotrophic denitrification and net NO sinks in iron-carbon amended ecological ditch.
Water Res
December 2024
School of Environment, Nanjing Normal University, Jiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response Technology, Jiangsu Engineering Lab of Water and Soil Eco-remediation, Wenyuan Road 1, Nanjing 210023, PR China. Electronic address:
Coupling of iron-carbon can form a mixotrophic denitrification and is regarded as a promising solution for purifying nitrate-rich agricultural runoff. However, its prevalence and efficacy of the synergistic augmentation of nitrogen elimination and net NO sinks remain crucial knowledge gaps in ecological ditches (eco-ditches). Here, we investigated the underlying variability mechanisms by implementing sponge iron (sFe)-coupled Iris hexagonus (IH)- or Myriophyllum aquaticum (MA)-derived biochar produced via microwave-assisted (MW) pyrolysis and conventional pyrolysis.
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