Negative inhibition is poor in sub-threshold depression individuals: Evidence from ERP and a Go/No-go task.

In this study, Go/No-go task combined with ERP technology were used to explore the characteristics of negative emotion inhibition in SD and healthy individuals and whether there are differences between negative emotion inhibition and neutral emotion inhibition in SD. The results showed that SD showed the same poor negative inhibition as depressive patients in behavior, but there was no significant difference between SD and CG in ERPs. Overall, compared with neutral emotional information, negative emotional information would reduce attention control in conflict processing, lead to faster conflict processing, attract attention, occupy more cognitive resources, and be more difficult to inhibit. It is concluded that the negative attention bias of SD individuals is only reflected in the bottom-up stimulation processing, but has not developed into the top-down cognitive control, which also suggests that the corresponding intervention measures at the early stage of depression may have better effects.