AI Article Synopsis
- The study focuses on dogs with functional pheochromocytomas, which are tumors that produce catecholamines and lead to heart issues.
- It details postmortem findings in twelve dogs, average age 10.6 years, revealing heart enlargement, left ventricular hypertrophy, and signs of cardiomyocyte damage and inflammation.
- The research suggests that immunohistochemical analysis for cardiac troponin C can effectively identify early myocardial necrosis, even when visible changes in heart cells are minimal.
Article Abstract
Functional pheochromocytomas secrete catecholamines and have been associated with cardiovascular lesions in dogs. This study aimed to describe the postmortem pathological findings in the cardiovascular system of dogs with pheochromocytoma and to evaluate the expression of cardiac troponin C in these dogs using immunohistochemical analysis. Twelve cases were identified, with a mean age of 10.6 years. The heart of all dogs was enlarged and with concentric hypertrophy of the left ventricular myocardium. Histological analysis showed cardiomyocyte necrosis and degeneration in the myocardium, with frequent bands of contraction, fibrosis, inflammation, and thickening of the medium-caliber arteries in the myocardium. There was a marked decrease or absence of immunolabeling in necrotic cardiomyocytes. We conclude that IHC for troponin C can be a useful tool for detecting myocardial necrosis in dogs with pheochromocytomas, including early cases of necrosis with only incipient cardiac changes where overt histologic abnormalities are not immediately apparent in the cardiomyocytes.
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| http://dx.doi.org/10.1016/j.tcam.2023.100777 | DOI Listing |
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