AI Article Synopsis
- - The proteasome plays a crucial role in regulating cellular functions and maintaining balance in biological systems, and it is particularly important in understanding diseases like neurodegenerative conditions, immune disorders, and various cancers, notably multiple myeloma and mantle cell lymphoma.
- - Current proteasome inhibitors work by binding to the proteasome's active site, using a competitive mechanism, but treatment complications like resistance lead to the need for alternative inhibitors.
- - This review focuses on noncompetitive proteasome inhibitors, detailing how they work, their potential uses, and their pros and cons compared to traditional competitive inhibitors.
Article Abstract
The proteasome regulates intracellular processes, maintains biological homeostasis, and has shown great significance in the study of various diseases, such as neurodegenerative diseases, immune-related diseases, and cancer, especially in hematologic malignancies such as multiple myeloma (MM) and mantle cell lymphoma (MCL). All clinically used proteasome inhibitors bind to the active site of the proteasome and thus exhibit a competitive mechanism. The development of resistance and intolerance during treatment drives the search for inhibitors with different mechanisms of action. In this review, we provide an overview of noncompetitive proteasome inhibitors, including their mechanisms of action, function, possible applications, and their advantages and disadvantages compared with competitive inhibitors.
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| http://dx.doi.org/10.1016/j.bioorg.2023.106507 | DOI Listing |
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