AI Article Synopsis
- The study explores the potential relationship between preoperative serum uric acid levels, albumin levels, and their ratio in predicting lymph node metastasis in non-small cell lung cancer patients undergoing surgery.
- Researchers reviewed medical records of 115 patients who had surgery for lung cancer, determining critical cutoff values for uric acid and its ratio to albumin using ROC analysis.
- Findings revealed a significant correlation, suggesting that higher preoperative uric acid levels and uric acid to albumin ratios may indicate a higher risk of lymph node metastasis in affected patients.
Article Abstract
Objectives: In recent years, a correlation between prognosis of various cancers and inflammation has been emphasized in many studies. Uric acid which is a purine metabolite is one of the serum inflammation markers. Albumin is a major component of serum protein and it is used as a parameter reflecting nutritional status and cancer aggressiveness. Here, we have investigated whether preoperative serum uric acid levels, albumin levels, and uric acid to albumin ratio predict lymph node metastasis in non-small cell lung cancer treated surgically by VATS.
Methods: The medical records of patients underwent VATS lobectomy-segmentectomy for non-small cell lung cancer between January 2015 and December 2020, were reviewed retrospectively. Cut-off values of preoperative serum uric acid, albumin and uric acid to albumin ratio were determined by Receiver Operating Characteristics (ROC) analysis. Groups with and without lymph node metastasis were created according to hilar and/or mediastinal lymph node metastasis. In addition, high and low groups were created according to preoperative uric acid levels and uric acid to albumin ratio. Pearson chi-square test was used investigate whether any significant correlation between the groups.
Results: A total of 115 patients were included in the study. Lymph node metastasis in N1 and N2 stations was detected in 11 and 18 patients, respectively. Cut-off values for uric acid and uric acid to albumin ratio were 5.97 mg/dL and 1.28x10-3, respectively. There was a statistically significant correlation between lymph node metastasis and high uric acid levels (p=0.008, OR: 3.2) and high uric acid to albumin ratio (p=0.03, OR: 2.6).
Conclusion: Preoperative serum uric acid and uric acid to albumin ratio can predict the lymph node metastasis in non-small cell lung cancer treated surgically by video assisted thoracic surgery.
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| http://dx.doi.org/10.48729/pjctvs.249 | DOI Listing |
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