Objective was to compare the effect of functionalization of magnetite (FeO) nanoparticles (NPs) with sodium chloride (NaCl), or its combination with ethylmethylhydroxypyrydine succinate (EMHPS) and polyvinylpyrrolidone (PVP) on blood gases and electrolytes in acute blood loss. Ligandless magnetite NPs were synthesized by the electron beam technology and functionalized by mentioned agents. Size of NPs in colloidal solutions FeO@NaCl, FeO@NaCl@EMHPS, FeO@NaCl@PVP, FeO@NaCl@EMHPS@PVP (nanosystems 1-4) was determined by dynamic light scattering. In vivo experiments were performed on 27 Wistar rats. Acute blood loss was modeled by removal 25 % circulating blood. Nanosystems 1-4 were administered to animals intaperitoneally after the blood loss with followed determination of blood gases, pH and electrolytes. In blood loss, nanosystems FeO@NaCl and FeO@NaCl@PVP were able to improve the state of blood gases, pH, and the ratio of sodium/potassium in the blood. So, magnetite NPs with a certain surface modification can promote oxygen transport under hypoxic conditions.
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| http://dx.doi.org/10.1016/j.nano.2023.102675 | DOI Listing |
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