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Evaluation of Retinal Sensitivity in Complete Retinal-Pigment-Epithelium and Outer Retinal Atrophy (cRORA) Lesions in Intermediate Age-Related Macular Degeneration (iAMD) by High-Resolution Microperimetry.
J Clin Med
December 2024
Department of Ophthalmology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
: Lesions characterized as complete retinal pigment epithelium and outer retinal atrophy (cRORA) are linked to the progression of intermediate age-related macular degeneration (iAMD). However, the extent of functional impairment of such precursor lesions remains uncertain. : In this cross-sectional study, 4 participants (mean age ± standard deviation: 71.
View Article and Find Full Text PDFComprehensive study of SNAREs involved in the post-Golgi transport in photoreceptors.
Front Cell Dev Biol
December 2024
Program of Life and Environmental Science, Graduate School of Integral Science for Life, Hiroshima University, Hiroshima, Japan.
Polarized transport is essential for the construction of multiple plasma membrane domains within cells. photoreceptors serve as excellent model systems for studying the mechanisms of polarized transport. We conducted a comprehensive soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) screening of the fly genome using RNAi knockdown and CRISPR/Cas9 somatic knockout combined with the CoinFLP system to identify SNAREs involved in post-Golgi trafficking.
View Article and Find Full Text PDFRetinal Sensitivity in Comparison to Cone Density in Choroideremia.
Invest Ophthalmol Vis Sci
December 2024
Scheie Eye Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, United States.
Purpose: Choroideremia (CHM) is an X-linked inherited retinal degeneration causing loss of photoreceptors, retinal pigment epithelium, and choriocapillaris. Structural abnormalities of the cone photoreceptor mosaic have been reported even within the retained island of functioning retina. Here, we describe the relationship between cone density and visual sensitivity within the retained central retina in CHM.
View Article and Find Full Text PDFSeasonal Variation in ATP-Induced Retinal Damage in the Cone-Dominant 13-Lined Ground Squirrel.
Transl Vis Sci Technol
November 2024
Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Article Synopsis
- The study investigates how the timing of hibernation affects retinal damage in 13-lined ground squirrels after injecting them with adenosine triphosphate (ATP).
- Eighteen squirrels were divided into three groups based on the season (early, mid, late) and underwent imaging before and after ATP injection to assess retinal health.
- Results indicated that early-season squirrels were more likely to suffer retinal damage, and further research is suggested to refine ATP dosing based on seasonal ocular changes.
Comparison of the Photoreceptor Mosaic Before and After Macular Hole Surgery With High-Resolution Adaptive Optics Imaging.
Am J Ophthalmol
October 2024
From the Department of Ophthalmology and Vision Sciences, University of Toronto (P.L.O., T.W., S.C.N., M.C.P., H.H., M.I., F.N., P.Y., R.H.M.), Toronto, Ontario, Canada; Department of Ophthalmology, St. Michael's Hospital, Unity Health Toronto (P.L.O., M.C.P., H.H., F.N., P.Y., R.H.M.), Toronto, Ontario, Canada; Kensington Vision and Research Institute (T.W., P.Y., R.H.M.), Toronto, Ontario, Canada. Electronic address:
Article Synopsis
- This study evaluated the photoreceptor mosaic in patients with idiopathic full thickness macular holes before and after surgery using adaptive optics imaging.* -
- Conducted at the Kensington Eye Institute, the research excluded patients with certain conditions and involved detailed measurements of cone density and regularity in the retina.* -
- Results showed a significant decrease in cone density and changes in spacing and dispersion three months post-surgery, demonstrating the effectiveness of adaptive optics for assessing retinal health.*
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