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| http://dx.doi.org/10.1016/j.stem.2023.02.005 | DOI Listing |
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Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas.
Cell Stem Cell
April 2023
Cancer Stem Cell Laboratory, Institute of Cancer Research, London, UK; Imperial College, Division of Cancer, Department of Surgery and Cancer, London, SW7 2BU, UK; Convergence Science Centre, Imperial College, London, SW7 2BU, UK. Electronic address:
Pancreatic beta cell neogenesis: Debates and updates.
Cell Metab
November 2021
State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address:
Finding endogenous, renewable sources for insulin-producing beta cells in the adult pancreas is one of the holy grails of stem cell research and regenerative medicine. Through lineage tracing and scRNA-seq approaches, Gribben et al. (2021) have recently reported that Ngn3-expressing ductal cells could serve as progenitors for new beta cells in the adult pancreas.
View Article and Find Full Text PDFDuctal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas.
Cell Stem Cell
November 2021
The Francis Crick Institute, 1 Midland Road, London, UK; Cancer Stem Cell Laboratory, Institute of Cancer Research, London, UK; Division of Cancer, Department of Surgery and Cancer, Imperial College, London, UK; Convergence Science Centre, Imperial College, London SW7 2BU, UK. Electronic address:
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the β cell population over time. Lineage tracing using the Neurogenin3 (Ngn3)-CreERT line identified ductal cells expressing the endocrine master transcription factor Ngn3 that were positive for the δ cell marker somatostatin and occasionally co-expressed insulin.
View Article and Find Full Text PDFDiabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice.
Sci Rep
February 2016
Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Endocrine and exocrine pancreas tissues are both derived from the posterior foregut endoderm, however, the interdependence of these two cell types during their formation is not well understood. In this study, we generated mutant mice, in which the exocrine tissue is hypoplastic, in order to reveal a possible requirement for exocrine pancreas tissue in endocrine development and/or function. Since previous studies showed an indispensable role for Pdx1 in pancreas organogenesis, we used Elastase-Cre-mediated recombination to inactivate Pdx1 in the pancreatic exocrine lineage during embryonic stages.
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