Alzheimer's disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippocampal-dependent behaviors. Li et al. report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral symptoms and plaque deposition in AD mouse models. This supports boosting adult neurogenesis as a potential therapeutic approach for AD-related cognitive decline.
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| http://dx.doi.org/10.1016/j.stem.2023.03.012 | DOI Listing |
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Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice.
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Department of Psychiatry, Division of Systems Neuroscience, Columbia University, New York State Psychiatric Institute, New York, New York.
Background: Impairments in behavioral pattern separation (BPS)-the ability to distinguish between similar contexts or experiences-contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder, dementia, and age-related cognitive decline. Although BPS relies on the dentate gyrus and is sensitive to changes in adult hippocampal neurogenesis, its significance as a pharmacological target has not been tested.
Methods: In this study, we applied a human neural stem cell high-throughput screening cascade to identify compounds that increase human neurogenesis.
Role of Adenosine A1 Receptor in Sleep Deprivation-Induced Neuroinflammation: Insights on Rapid Eye Movement Sleep and Fear Extinction Memory Recall in Rats.
Cureus
December 2024
School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, IND.
Introduction: Sleep deprivation (SD), stemming from a myriad of aetiologies, is a prevalent health condition frequently overlooked. It typically impairs memory consolidation and synaptic plasticity, potentially through neuroinflammatory mechanisms and adenosinergic signalling. It is still unclear whether the adenosine A1 receptor (A1R) modulates SD-induced neurological deficits in the hippocampus.
View Article and Find Full Text PDFAdult Neurogenesis in the Subventricular Zone of Patients with Huntington's and Parkinson's Diseases and following Long-Term Treatment with Deep Brain Stimulation.
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Neurogenesis and Neurostereology laboratory, Biomedicine Institute-UCLM, Institute of Health Research of Castilla-La Mancha (IDISCAM), University of Castilla-La Mancha, Albacete, Spain. Electronic address:
The mammalian olfactory system is responsible for processing environmental chemical stimuli and comprises several structures, including the olfactory epithelium, olfactory bulb, olfactory peduncle (OP), and olfactory cortices. Despite the critical role played by the OP in the conduction of olfactory information, it has remained understudied. In this work, optical, confocal, and electron microscopy were employed to examine the anatomy, histology, and ultrastructure of six human OP specimens (ages 37-84 years).
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