Both network pruning and neural architecture search (NAS) can be interpreted as techniques to automate the design and optimization of artificial neural networks. In this paper, we challenge the conventional wisdom of training before pruning by proposing a joint search-and-training approach to learn a compact network directly from scratch. Using pruning as a search strategy, we advocate three new insights for network engineering: 1) to formulate adaptive search as a cold start strategy to find a compact subnetwork on the coarse scale; and 2) to automatically learn the threshold for network pruning; 3) to offer flexibility to choose between efficiency and robustness. More specifically, we propose an adaptive search algorithm in the cold start by exploiting the randomness and flexibility of filter pruning. The weights associated with the network filters will be updated by ThreshNet, a flexible coarse-to-fine pruning method inspired by reinforcement learning. In addition, we introduce a robust pruning strategy leveraging the technique of knowledge distillation through a teacher-student network. Extensive experiments on ResNet and VGGNet have shown that our proposed method can achieve a better balance in terms of efficiency and accuracy and notable advantages over current state-of-the-art pruning methods in several popular datasets, including CIFAR10, CIFAR100, and ImageNet. The code associate with this paper is available at: https://see.xidian.edu.cn/faculty/wsdong/Projects/AST-NP.htm.
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http://dx.doi.org/10.1109/TPAMI.2023.3248612 | DOI Listing |
Front Plant Sci
January 2025
College of Information Technology, Jilin Agricultural University, Changchun, China.
Introduction: Potatoes and tomatoes are important Solanaceae crops that require effective disease monitoring for optimal agricultural production. Traditional disease monitoring methods rely on manual visual inspection, which is inefficient and prone to subjective bias. The application of deep learning in image recognition has led to object detection models such as YOLO (You Only Look Once), which have shown high efficiency in disease identification.
View Article and Find Full Text PDFHereditary hemorrhagic telangiectasia is an autosomal dominant disorder caused by mutations in the bone morphogenetic protein signaling pathway, leading to arteriovenous malformations. While previously thought to share molecular and cellular dysregulation, this study reveals highly distinct mechanisms depending on whether mutations occur in Alk1 or SMAD4. Loss of SMAD4 enhances endothelial cell responses to flow, including flow-regulated transcription and cell migration against blood flow, causing excessive pruning of capillaries and the formation of single large shunts.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Department of Biology, Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA, USA. Electronic address:
The rapid turnover of branched actin networks underlies key in vivo processes such as lamellipodial extension, endocytosis, phagocytosis, and intracellular transport. However, our understanding of the mechanisms used to dissociate, or 'prune', branched filaments has remained limited. Glia maturation factor (GMF) is a cofilin family protein that binds to Arp2/3 complex and catalyzes branch dissociation.
View Article and Find Full Text PDFbioRxiv
October 2024
National Library of Medicine, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, 20894, USA.
AlphaFold2 (AF2), a deep-learning based model that predicts protein structures from their amino acid sequences, has recently been used to predict multiple protein conformations. In some cases, AF2 has successfully predicted both dominant and alternative conformations of fold-switching proteins, which remodel their secondary and tertiary structures in response to cellular stimuli. Whether AF2 has learned enough protein folding principles to reliably predict alternative conformations outside of its training set is unclear.
View Article and Find Full Text PDFComput Biol Med
January 2025
Department of Computer Science, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran. Electronic address:
Tiny machine learning (TinyML) and edge intelligence have emerged as pivotal paradigms for enabling machine learning on resource-constrained devices situated at the extreme edge of networks. In this paper, we explore the transformative potential of TinyML in facilitating pervasive, low-power cardiovascular monitoring and real-time analytics for patients with cardiac anomalies, leveraging wearable devices as the primary interface. To begin with, we provide an overview of TinyML software and hardware enablers, accompanied by an examination of networking solutions such as Low-power Wide area network (LPWAN) that facilitate the seamless deployment of TinyML frameworks.
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