Graph-based clustering approaches, especially the family of spectral clustering, have been widely used in machine learning areas. The alternatives usually engage a similarity matrix that is constructed in advance or learned from a probabilistic perspective. However, unreasonable similarity matrix construction inevitably leads to performance degradation, and the sum-to-one probability constraints may make the approaches sensitive to noisy scenarios. To address these issues, the notion of typicality-aware adaptive similarity matrix learning is presented in this study. The typicality (possibility) rather than the probability of each sample being a neighbor of other samples is measured and adaptively learned. By introducing a robust balance term, the similarity between any pairs of samples is only related to the distance between them, yet it is not affected by other samples. Therefore, the impact caused by the noisy data or outliers can be alleviated, and meanwhile, the neighborhood structures can be well captured according to the joint distance between samples and their spectral embeddings. Moreover, the generated similarity matrix has block diagonal properties that are beneficial to correct clustering. Interestingly, the results optimized by the typicality-aware adaptive similarity matrix learning share the common essence with the Gaussian kernel function, and the latter can be directly derived from the former. Extensive experiments on synthetic and well-known benchmark datasets demonstrate the superiority of the proposed idea when comparing with some state-of-the-art methods.
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http://dx.doi.org/10.1109/TNNLS.2023.3243914 | DOI Listing |
Cell Biochem Biophys
December 2024
School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, 464-8650, Japan.
Cell-extracellular matrix (ECM) interactions play multiple roles in developmental, physiological, and pathological processes. ECM stiffness substantially affects cellular morphology, migration, and function. In this study, we investigated the effect of ECM comprising gelatin methacryloyl (GelMA) on the activation of rat basophilic leukemia (RBL-2H3) cells, a model mast cell line.
View Article and Find Full Text PDFVestn Oftalmol
December 2024
Krasnov Research Institute of Eye Diseases, Moscow, Russia.
Unlabelled: Excessive production of extracellular matrix is a key component in the pathogenesis of Salzmann's nodular degeneration (SND). studies of drugs that suppress excessive fibroblast activity may become crucial in developing pathogenetically oriented treatments for SND.
Purpose: This study evaluates the antifibrotic properties of pirfenidone and cyclosporine A (CsA) on cell cultures obtained from patients with SND.
Sci Rep
December 2024
Department of Computer Engineering, Sharif University of Technology, Azadi Avenue, Tehran, Iran.
Numerous algorithms have been proposed to infer the underlying structure of the social networks via observed information propagation. The previously proposed algorithms concentrate on inferring accurate links and neglect preserving the essential topological properties of the underlying social networks. In this paper, we propose a novel method called DANI to infer the underlying network while preserving its structural properties.
View Article and Find Full Text PDFSci Rep
December 2024
Centre for Sustainable Materials and Surface Metamorphosis, Chennai Institute of Technology, Chennai, 600069, Tamilnadu, India.
This study investigates the production of graphene-enhanced polyethylene terephthalate glycol (G-PETG) components using fused deposition modeling (FDM) and evaluates their mechanical properties, contributing to the advancement of additive manufacturing. Trials demonstrated notable improvements in mechanical performance, with optimal printing parameters identified using the Spice Logic Analytical Hierarchy Process (AHP). The effectiveness of this methodology is further compared with the Fuzzy Analytic Hierarchy Process (FAHP) combined with the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS).
View Article and Find Full Text PDFPharmacol Res
December 2024
Department of Dermatology, University Medical Center of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany; Department of Medicine II, Saarland University Medical Center, Saarland University, Kirrberger Strasse 100, 66123 Saarbrücken, Germany. Electronic address:
Hepatocellular Carcinoma (HCC) is the most common form of primary liver cancer, with cirrhosis being its strongest risk factor. Interestingly, an increasing number of HCC cases is also observed without cirrhosis. We developed an HCC model via intrasplenic injection of highly tumorigenic HCC cells, which, due to cellular tropism, invade the liver and allow for a controllable disease progression.
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