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This case report describes a novel therapy for patients with severe autism spectrum disorder (ASD) that is worth further investigation. A 19-year-old male adolescent with ASD, who was not responding to standard treatment received fecal microbiota transplant (FMT) using donor material from his typically developing female sibling. The patient's ASD symptoms were assessed by assessors who were blind to the patient's past ASD symptomatology.
View Article and Find Full Text PDFMetastasizing pleomorphic adenoma of the parotid gland: A common tumour with a very unusual presentation.
Rev Esp Patol
April 2024
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Metastasizing pleomorphic adenoma is recognized as a subtype of pleomorphic adenoma in WHO classification 5th edition of salivary glands. The controversy pertaining to the entity is the benign features of the disease even at a metastatic site. We present a rare case of left recurrent pre-auricular swelling in a young male reported as metastasizing pleomorphic adenoma.
View Article and Find Full Text PDFGlucagon-like peptide-1 analog therapy in rare genetic diseases: monogenic obesity, monogenic diabetes, and spinal muscular atrophy.
Acta Diabetol
August 2023
Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann St, 64239-06, Tel Aviv, Israel.
Article Synopsis
- The study explores the use of liraglutide, a GLP-1 analogue, as an off-label therapy for patients with rare genetic causes of early-onset obesity and related complications.
- Three case studies demonstrated that liraglutide can significantly halt weight gain, improve metabolic parameters, and support overall health in affected individuals despite their complex genetic backgrounds.
- The findings suggest that liraglutide may have broader benefits beyond weight loss, making it a potentially valuable treatment option for managing obesity-related conditions in genetically predisposed patients.
Nineteen-Year-Old Male With Left Elbow Discomfort.
Am J Phys Med Rehabil
November 2023
From the Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota (JMR); Department of Physical Medicine and Rehabilitation, Mayo Clinic, Minneapolis, Minnesota (IH); and Department of Orthopedic Surgery, Division of Sports Medicine, Mayo Clinic, Minnesota (SJ).
Applying the PROSPER prevention delivery system with middle schools: Emerging adulthood effects on substance misuse and conduct problem behaviors through 14 years past baseline.
Child Dev
July 2022
Edna Bennett Pierce Prevention Research Center, Pennsylvania State University, University Park, Pennsylvania, USA.
This study evaluated emerging adult effects of the PROmoting School-Community-University Partnerships to Enhance Resilience (PROSPER) universal prevention delivery system implemented in middle schools. Twenty-eight rural school districts were randomized to intervention and control conditions, with 1985 nineteen-year-old participants (90.6% White, 54.
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