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| http://dx.doi.org/10.3389/fmolb.2023.1178488 | DOI Listing |
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OX40, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on the surface of activated T cells. Upon interaction with its cognate ligand, OX40L, OX40 transmits costimulatory signals to antigen-primed T cells, promoting their activation, differentiation, and survivalprocesses essential for the establishment of adaptive immunity. Although the OX40-OX40L interaction has been extensively studied in the context of disease treatment, developing a substitute for the naturally expressed membrane-bound OX40L, particularly a multimerized OX40L trimers, that effectively regulates OX40-driven T cell responses remains a significant challenge.
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Musicians and researchers are creative professions that share many similarities. They both aim to bring joy and progress to humanity. In recent decades, it has been shown that music has the ability to alleviate pain, improve heart function, reduce anxiety, and stimulate the release of endogenous opioids in the brain.
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Kiwifruit ()-derived actinidin, a cysteine protease, is renowned for its meat-tenderizing and milk-clotting activities. Despite its potential in various biotechnological applications, an efficient expression platform for actinidin production has not yet been developed. Instead, actinidin has traditionally been purified directly from the fruits of various plants.
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