AI Article Synopsis
- Current research indicates that axial skeleton magnetic resonance imaging (AS-MRI) is more effective than traditional bone scintigraphy (BS) for identifying bone metastases in high-risk prostate cancer patients, though BS remains common.
- A study reviewing 503 high-risk prostate cancer patients showed that AS-MRI detected bone metastases in 17.5% of cases, significantly differing in PSA and clinical variables compared to those without metastases.
- The study suggests that AS-MRI not only performs as well as or better than BS for detection, but also offers substantial cost savings for the healthcare system, with all patients receiving scans promptly within 14 days.
Article Abstract
Introduction: Current literature suggests that axial skeleton magnetic resonance imaging (AS-MRI) is more sensitive than Tc 99m bone scintigraphy (BS) for detecting bone metastases (BM) in high-risk prostate cancer (PCa). However, BS is still widely performed. Its diagnostic accuracy has been studied; however, its feasibility and cost implications are yet to be examined.
Methods: We reviewed all patients with high risk PCa undergoing AS-MRI over a 5-year period. AS-MRI was performed on patients with histologically confirmed PCa and either PSA > 20 ng/ml, Gleason ≥8, or TNM Stage ≥T3 or N1 disease. All AS-MRI studies were obtained using a 1.5-T AchievaPhilips™MRI scanner. We compared the AS-MRI positivity and equivocal rate with that of BS. Data were analysed according to Gleason score, T-stage and PSA. Multivariate logistic regression analyses were used to quantify the strength of association between positive scans and clinical variables. Feasibility and burden of expenditure was also evaluated.
Results: Five hundred three patients with a median age of 72 and a mean PSA of 34.8 ng/ml were analysed. Eighty-eight patients (17.5%) were positive for BM on AS-MRI (mean PSA 99 [95% CI 69.1-129.9]). Comparatively 409 patients (81.3%) were negative for BM on AS-MRI (mean PSA 24.7 (95% CI [21.7-27.7]) ( = 0.007); 1.2% ( = 6) of patients had equivocal results (mean PSA 33.4 [95% CI 10.5-56.3]). There was no significant difference in age ( = 0.122) between this group and patients with a positive scan, but there was a significant difference in PSA ( = 0.028), T stage ( = 0.006) and Gleason score ( = 0.023). In comparison with BS, AS-MRI detection rate was equivalent or higher compared with the literature. Based on NHS tariff calculations, there would be a minimum cost saving of £8406.89. All patients underwent AS-MRI within 14 days.
Conclusion: The use of AS-MRI to stage BM in high-risk PCa is both feasible and results in a reduced burden of expenditure.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071081 | PMC |
| http://dx.doi.org/10.1002/bco2.210 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Accuracy of Controlled Attenuation Parameter for Liver Steatosis in High-Risk Patients for MASLD Using MRI-Proton Density Fat Fraction as Reference Standard.
Dig Dis Sci
December 2024
Second Medical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Aim: Controlled attenuation parameter (CAP) enables the noninvasive diagnosis of liver steatosis. Magnetic resonance imaging proton density fat fraction (MRI-PDFF) is increasingly used over biopsy for the assessment of steatosis in patients at risk for metabolic dysfunction-associated steatotic liver disease (MASLD). We assessed the accuracy of CAP for liver steatosis defined as MRI-PDFF ≥ 5%.
View Article and Find Full Text PDFHRS Improves Active Surveillance for Prostate Cancer by Timely Identification of Progression.
Acad Radiol
December 2024
Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, USA (I.M.K., V.W., E.I.Z., A.L.B., A.A., S.C., S.M.G., M.C.A., A.P., R.S.); Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA (S.M.G., O.N.K., M.C.A., C.R.R., B.N., M.L.G., D.J.P., A.P., S.P., R.S.). Electronic address:
Rationale And Objectives: Active surveillance (AS) is the preferred management strategy for low-risk prostate cancer. This study aimed to evaluate the impact of Habitat Risk Score (HRS), an automated approach for mpMRI analysis, for early detection of progressors in a prospective AS clinical trial (MAST NCT02242773).
Materials And Methods: The MAST protocol includes Confirmatory mpMRI ultrasound fusion (MRI-US) biopsy and yearly surveillance MRI-US biopsies for up to 3 years.
Clinicopathological Parameters and Immunohistochemical Profiles in Correlation with MRI Characteristics in Glioblastomas.
Int J Mol Sci
December 2024
Department of Anatomy and Embryology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mures, 38 Gheorghe Marinescu Str., 540142 Târgu Mures, Romania.
Glioblastoma is considered the most aggressive tumor of the central nervous system. The tumor microenvironment includes several components, such as endothelial cells, immune cells, and extracellular matrix components like matrix metalloproteinase-9 (MMP-9), which facilitates the proliferation of endothelial cells with pro-angiogenic roles. The MRI characteristics of glioblastomas can contribute to determining the prognosis.
View Article and Find Full Text PDFIs There a Need for Functional Radiographs in Diagnosing Lumbar Instability?
Global Spine J
December 2024
Department of Orthopedics, Medical University of Vienna, Vienna, Austria.
Study Design: Retrospective radiological database analysis.
Objective: The aim of this study was to assess the value of functional radiography (FRF = flexion; FRE = extension) compared to MRI and standing sagittal plane full spine radiography (SP) with low-grade spondylolisthesis.
Methods: Sagittal translation (ST) and rotation (SR) were measured between all lumbar levels to assess instability.
Advances in Diagnostic Parameters and Surgical Techniques for Patellofemoral Instability and Extensor Mechanism Disorders: A Comprehensive Review.
Cureus
November 2024
Orthopedics and Trauma, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Extensor mechanism misalignment in the knee, particularly patellofemoral instability (PFI), requires detailed diagnostic and therapeutic approaches. This comprehensive review intends to present recent advancements in diagnostic imaging technologies as well as surgical approaches that have significantly advanced the management of this condition. An extensive literature review covered recent studies and clinical practices related to diagnosing and treating knee extensor mechanism misalignment, such as three-dimensional imaging technologies, arthroscopic surgical techniques, postoperative rehabilitation protocols, and others.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!