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Penetrating intraorbital wooden foreign bodies involving the right frontal lobe of the brain: A rare case report.
Surg Neurol Int
November 2024
Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Universitas Brawijaya/Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia.
Background: Penetrating orbital trauma from a wooden foreign object is rare and challenging to identify, as it cannot be detected with a computed tomography (CT) scan. This report highlights the clinical presentation, diagnosis, and management of such a case.
Case Description: A 19-year-old female experienced penetrating orbital trauma from a wooden object following a traffic accident.
Primary Dengue and Long-Term Health Status in Madeira Island, Portugal: A Retrospective Questionnaire-Based Study.
Am J Trop Med Hyg
August 2024
Projeto Medicina, Faculdade de Ciências da Vida, Universidade da Madeira, Funchal, Portugal.
Dengue is among the most important mosquito-borne viral diseases worldwide. Although its acute manifestations are well known, little is known about the long-term impact of dengue on the population's health status. Madeira Island experienced a single outbreak of autochthonous dengue from September 2012 to March 2013.
View Article and Find Full Text PDFEffect of quercetin against pilocarpine-induced epilepsy in mice.
J Adv Pharm Technol Res
May 2024
Department of Clinical Pharmacy, College of Pharmacy, Tikrit University, Tikrit, Iraq.
Globally, an estimated 50 million people are affected by epilepsy, a persistent, noncommunicable neurological ailment. Quercetin (QR) is a prevalent flavonoid substance extensively dispersed throughout agricultural life. In a pilocarpine (PILO)-induced epilepsy model in mice, this investigation aimed to determine whether QR has an antiepileptic effect and explore its putative mechanism of action.
View Article and Find Full Text PDFIntestinal permeability is associated with aggravated inflammation and myofibroblast accumulation in Graves' orbitopathy: the MicroGO study.
Front Endocrinol (Lausanne)
December 2023
Department of (Experimental) Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centre (UMC), University of Amsterdam, Amsterdam, Netherlands.
Background: Graves' disease (GD) and Graves' orbitopathy (GO) result from ongoing stimulation of the TSH receptor due to autoantibodies acting as persistent agonists. Orbital pre-adipocytes and fibroblasts also express the TSH receptor, resulting in expanded retro-orbital tissue and causing exophthalmos and limited eye movement. Recent studies have shown that GD/GO patients have a disturbed gut microbiome composition, which has been associated with increased intestinal permeability.
View Article and Find Full Text PDFSelective Targeting of Nanobody-Modified Gold Nanoparticles to Distinct Cell Types.
ACS Appl Mater Interfaces
December 2023
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Nanobody-modified gold nanoparticles were used to explore their ability to achieve selective targeting in vitro and in vivo to distinct cell type(s), based on the specificity of the nanobody that was installed. We developed conjugation methods that exploit click chemistry for octahedral ∼50 nm gold nanoparticles and chiral ∼180 nm gold nanoparticles. We determined that each of these particles could be modified with ∼75 and ∼330 nanobodies, respectively.
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