In this issue of Neuron, Yang et al. highlight a hitherto unknown action of cocaine in VTA circuitry. They found that chronic cocaine use increased tonic inhibition selectively onto GABA neurons through Swell1 channel-dependent GABA release from astrocytes, leading to disinhibition-mediated hyperactivity in DA neurons and addictive behavior.
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| http://dx.doi.org/10.1016/j.neuron.2023.03.004 | DOI Listing |
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