Four new alkaloids, hippobrines A-D (-), along with three new polyacetylenes, hippobrenes A-C (-), were isolated from . Compounds - possess an unprecedented carbon skeleton. All of the new structures were determined by analyzing their mass and NMR spectroscopic data. The absolute configurations of and were confirmed by single-crystal X-ray analyses, and the absolute configurations of and were deduced using their ECD spectra. Plausible biogenetic pathways of and were proposed. In regard to bioactivities, all compounds (-) exhibited weak antiangiogenic activity against human endothelial progenitor cells, with IC values ranging from 21.1 ± 1.1 to 44.0 ± 2.3 μg/mL.
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