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Structural remodeling of the brain cortex and functional recovery following hypoglossal-facial neurorrhaphy in patients with facial paralysis.
Brain Res
February 2025
Beijing Key Laboratory of Central Nervous System Injury, Beijing Neurosurgical Institute, Capital Medical University, Beijing 10070, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 10070, China; U1195, Inserm et Universite Paris-Saclay, 94276 Le Kremlin-Bicetre, France. Electronic address:
Objective: Peripheral nerve injury results in functional alterations of the corresponding active brain areas, which are closely related to functional recovery. Whether such functional plasticity induces relative anatomical structural changes remains to be investigated.
Methods: In this study, we investigated the changes in brain cortical thickness in patients with facial paralysis following neurorrhaphy treatment at different follow-up times.
Current perspectives on the use of GLP-1 receptor agonists in obesity-related obstructive sleep apnea: a narrative review.
Expert Opin Pharmacother
January 2025
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Article Synopsis
- Traditional treatments for obstructive sleep apnea (OSA) mainly focus on methods like continuous positive airway pressure therapy and oral appliances, but they don't tackle the underlying metabolic issues that contribute to the condition.
- Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially created for managing type 2 diabetes, show promise in helping obese patients with OSA by promoting significant weight loss and reducing fat around the airway.
- Emerging research indicates that integrating GLP-1 RAs into standard OSA treatments could improve patient outcomes by addressing both obesity and related health issues, potentially changing the way OSA is managed in the future.
The Emerging Role of Pharmacotherapy in Obstructive Sleep Apnea.
J Otorhinolaryngol Hear Balanc Med
December 2024
Section of Pulmonary, Critical Care, and Sleep Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Obstructive sleep apnea (OSA) is a prevalent pathology with current modalities of treatment including continuous positive airway pressure (CPAP), surgery, weight loss, hypoglossal nerve stimulation, and pharmacotherapy. While CPAP is the current standard treatment for OSA, lack of tolerance and side effects necessitate alternative modalities of treatment. Various pharmacologic agents exist with mechanisms that may target OSA.
View Article and Find Full Text PDFOlfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity.
J Virol
November 2024
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Article Synopsis
- HSV-1 primarily infects the oral and nasal areas before establishing latency in the trigeminal ganglion and can also infect the central nervous system (CNS) via specific pathways.
- Recent studies have highlighted the lack of detailed knowledge about which brain regions are affected during HSV-1 infections and how microglial responses differ across these regions.
- This study on a mouse model revealed a two-step spread of HSV-1 from the olfactory epithelium to select brain regions, along with varying activation levels of microglia, contributing to understanding HSV-1's role in neurological diseases.
Surgery for facial palsy in the hands of otorhinolaryngologists: a population-based study.
Eur Arch Otorhinolaryngol
October 2024
Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.
Purpose: Modern facial surgery can improve eye closure and address facial functional and emotional expression disabilities in case of severe acute facial paralysis with low probability of recovery and in cases of chronic flaccid facial paralysis. Reports on outcome typically originate from specialized tertiary care centers, whereas population-based data from routine care beyond specialized centers is sparse.
Methods: Therefore, patients' characteristics, surgical techniques, postoperative complications, and patients' satisfaction with the final outcome were analyzed for all inpatients with facial paralysis undergoing facial surgery in Thuringia, a federal state in Germany, between 2006 and 2022.
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