Community detection aims at finding all densely connected communities in a network, which serves as a fundamental graph tool for many applications, such as identification of protein functional modules, image segmentation, social circle discovery, to name a few. Recently, nonnegative matrix factorization (NMF)-based community detection methods have attracted significant attention. However, most existing methods neglect the multihop connectivity patterns in a network, which turn out to be practically useful for community detection. In this article, we first propose a novel community detection method, namely multihop NMF (MHNMF for brevity), which takes into account the multihop connectivity patterns in a network. Subsequently, we derive an efficient algorithm to optimize MHNMF and theoretically analyze its computational complexity and convergence. Experimental results on 12 real-world benchmark networks demonstrate that MHNMF outperforms 12 state-of-the-art community detection methods.
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http://dx.doi.org/10.1109/TNNLS.2023.3238419 | DOI Listing |
Oncol Lett
March 2025
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600077, India.
The present study investigated the involvement of human papillomavirus (HPV)16 and HPV18 in oropharyngeal malignancies in order to understand the oncogenic mechanisms, and to identify biomarkers for early detection and treatment targets. Given the rising incidence of HPV-associated cancer, particularly in India, this holds significance in elucidating the molecular basis of these diseases. Structural validation of HPV16 and 18 oncoproteins E6 and E7 was conducted using computational tools, while gene expression profiles related to oral squamous cell carcinoma (OSCC) were analyzed to assess differential expression.
View Article and Find Full Text PDFBMJ Open
December 2024
Department of Pediatrics, Khon Kaen University Faculty of Medicine, Khon Kaen, Thailand.
Objective: Infants are at a high risk of developing anaemia, which can arise from various causes, including inappropriate feeding practices. However, few infants attend anaemia screening programmes due to poor cooperation and being time-consuming. This study evaluated the accuracy of noninvasive total haemoglobin (Hb) spot-check monitoring as part of anaemia screening in healthy infants, compared with the conventional laboratory method.
View Article and Find Full Text PDFBMJ Open
December 2024
Perinatal HIV Research Unit (PHRU), University of the Witwatersrand Johannesburg, Johannesburg, Gauteng, South Africa.
Purpose: In the setting of an established childhood pneumococcal vaccination programme with immediate initiation and treatment of antiretroviral therapy (ART) for people living with HIV (PLWH), the risk of adult pneumococcal community-acquired pneumonia (CAP) is not recently described. We aimed to investigate CAP incidence, recurrence, mortality, risk factors and microbiology before and during the COVID-19 pandemic.
Participants: Adults aged ≥18 years were enrolled in three South African provinces from March 2019 to October 2021, with a brief halt during the initial COVID-19 lockdown.
BMJ Open
December 2024
Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA.
Introduction: Early lung cancer screening (LCS) through low-dose CT (LDCT) is crucial but underused due to various barriers, including incomplete or inaccurate patient smoking data in the electronic health record and limited time for shared decision-making. The objective of this trial is to investigate a patient-centred intervention, MyLungHealth, delivered through the patient portal. The intervention is designed to improve LCS rates through increased identification of eligible patients and informed decision-making.
View Article and Find Full Text PDFBMJ Open
December 2024
National School of Public Health, Universidade NOVA de Lisboa, Lisbon, Portugal.
Objective: To explore the perceptions of migrant women, healthcare professionals and community workers regarding migrant women's knowledge and attitudes about cervical cancer (CC) and screening and how these influence cervical cancer screening (CCS) uptake.
Design: Qualitative study with seven focus groups, using a semistructured guide.
Setting: Five focus groups were conducted online and two in community associations in Lisbon, Portugal.
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