A highly site-selective trifluoromethylaminoxylation of activated and unactivated olefins was reported under metal-free conditions. The method provides direct access to diverse β-trifluoromethyl trisubstituted hydroxylamines, tertiary alcohols, isoxazolines, isoxazolidines, and amino alcohols. The SET process between hydroxylamine and the hypervalent iodine-CF reagent is proposed to produce two free radicals for the regio- and diastereoselective addition to alkenes. The synthetic potential of the protocol was established via the late-stage functionalization of the products and a series of postreaction modifications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.3c00951 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Morphogenesis of Aragonite Biomineral Structures by the Nonclassical Colloidal Crystal Growth Mechanism Revisited on the Nanoscale: The Noah's Ark Shell (, L.) Case Study.
ACS Biomater Sci Eng
January 2025
Advanced Materials Department, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.
Characterization and formation of the biomineral aragonite structures of the Noah's Ark shell ( L.,1758) were studied from structural, morphogenetic, and biochemical points of view. Structural and morphological features were examined using X-ray diffraction, field-emission scanning electron microscopy, and atomic force microscopy, while thermal properties were determined by thermogravimetric and differential thermal analyses.
View Article and Find Full Text PDF[Approach to Scabies in Children: An Update].
Acta Med Port
January 2025
Serviço de Dermatologia. Unidade Local de Saúde Santo António. Porto. Portugal.
Scabies is a common dermatological infection that globally affects more than 200 million people. It is caused by the parasite Sarcoptes scabiei var. hominis and its transmission primarily occurs through direct contact.
View Article and Find Full Text PDFTransformers for Neuroimage Segmentation: Scoping Review.
J Med Internet Res
January 2025
Department of Computer Science and Software Engineering, United Arab Emirates University, Al Ain, United Arab Emirates.
Background: Neuroimaging segmentation is increasingly important for diagnosing and planning treatments for neurological diseases. Manual segmentation is time-consuming, apart from being prone to human error and variability. Transformers are a promising deep learning approach for automated medical image segmentation.
View Article and Find Full Text PDFUnderstanding Individual Differences in Happiness Sources and Implications for Health Technology Design: Exploratory Analysis of an Open Dataset.
JMIR Form Res
January 2025
School of Psychology, Ulster University, Coleraine, United Kingdom.
Background: Psychologists have developed frameworks to understand many constructs, which have subsequently informed the design of digital mental health interventions (DMHIs) aimed at improving mental health outcomes. The science of happiness is one such domain that holds significant applied importance due to its links to well-being and evidence that happiness can be cultivated through interventions. However, as with many constructs, the unique ways in which individuals experience happiness present major challenges for designing personalized DMHIs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!