AI Article Synopsis
- Conventional cancer treatments often have undesirable side effects that limit their effectiveness.
- Researchers are exploring alternative methods that target specific biochemical characteristics of cancer cells, such as hypoxia, to induce cell death.
- A new agent called biotinylated Co-integrated carbon dot (CoCD) has been developed, which selectively kills cancer cells by promoting hypoxia-induced apoptosis, showing higher efficiency in cancer cells compared to non-cancer cells.
Article Abstract
Conventional cancer treatments have systematic side effects that stand against its desirable therapeutic efficacy. Alternative strategies using biochemical features of cancer cells to promote apoptosis are finding notable significance. One such important biochemical feature of malignant cells is hypoxia, alteration of which can lead to cell death. Hypoxia inducible factor 1α (HIF-1α) has the key role in hypoxia generation. Herein, we synthesized biotinylated Co -integrated carbon dot (CoCD ) that specifically diagnose and selectively killed cancer cells with 3-3.1-fold higher efficiency over non-cancer cells by hypoxia induced apoptosis in absence of traditional therapeutic intervention. Immunoblotting assay in CoCD treated MDA-MB-231 cells confirmed the increased expression of HIF-1α that was responsible for efficient killing of cancer cells. In 2D cells and 3D tumor spheroid, CoCD treated cancer cells showed significant apoptosis that make CoCD a potential theranostic agent.
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| http://dx.doi.org/10.1002/chem.202300928 | DOI Listing |
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