Method: A systematic literature search was conducted using the key words 'naltrexone', 'fibromyalgia', 'fibrositis', 'chronic pain' and 'neurogenic inflammation'.
Results: Manual exclusion led to the identification of 21 papers, with only five prospective controlled trials of low sample size.
Discussion: Low-dose naltrexone may be an effective and safe pharmacotherapy for patients with fibromyalgia. Current evidence lacks power and multisite reproduction.
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| http://dx.doi.org/10.31128/AJGP-09-22-6564 | DOI Listing |
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