AI Article Synopsis
- * A specific case showed a metastatic germ cell tumor with 30% PD-L1 positive cells responded well to the monoclonal antibody toripalimab, leading to lasting remission.
- * After 36 months of follow-up, the patient maintained remission despite stopping toripalimab after 18 months due to an allergic reaction, suggesting its potential as a salvage therapy.
Article Abstract
The outcome for patients with recurrent and metastatic germ cell tumors can be dismal, and novel salvage therapies are required for these patients. Here we describe a case of metastatic germ cell tumor in which 30% of cells were positive for PD-L1. This tumor achieved a durable response to toripalimab, a monoclonal anti-PD-1 antibody. Follow-up for 36 months post-treatment confirmed no disease progression. Continuous remission was maintained even when treatment was interrupted after 18 months because of an immune-related adverse event (allergic rhinitis). Thus, toripalimab may be an alternative choice for salvage therapy in patients with recurrent and metastatic germ cell tumors.
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| http://dx.doi.org/10.2217/imt-2022-0228 | DOI Listing |
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