Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41584-023-00962-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis.
Autoimmunity
December 2024
Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease, and understanding its genetic and molecular basis is crucial for early diagnosis, treatment, and prevention.
Objective: This study aims to explore the association between polymorphisms (rs2227284, rs2243267, rs2243270, and rs2243283) and RA risk.
Methods: The four polymorphisms were genotyped in 493 RA patients and 493 healthy controls using Agena MassARRAY.
The prevalence and risk factors of rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis.
Ann Med
December 2024
Center of Clinical Evaluation and Analysis, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine).
Background: Interstitial lung disease (ILD) is the most widespread and fatal pulmonary complication of rheumatoid arthritis (RA). Existing knowledge on the prevalence and risk factors of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is inconclusive. Therefore, we designed this review to address this gap.
View Article and Find Full Text PDFMachine learning-based prediction of rheumatoid arthritis with development of ACPA autoantibodies in the presence of non-HLA genes polymorphisms.
PLoS One
March 2024
Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
Machine learning (ML) algorithms can handle complex genomic data and identify predictive patterns that may not be apparent through traditional statistical methods. They become popular tools for medical applications including prediction, diagnosis or treatment of complex diseases like rheumatoid arthritis (RA). RA is an autoimmune disease in which genetic factors play a major role.
View Article and Find Full Text PDFShift in perspective: autoimmunity protecting against rheumatoid arthritis.
Ann Rheum Dis
April 2024
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden
Article Synopsis
- Rheumatoid arthritis (RA) is linked to high levels of special proteins called autoantibodies that can start the disease.
- Scientists found that some of these autoantibodies can actually help protect mice from arthritis instead of causing it.
- They also discovered that healthy people have special immune cells that decrease in number in RA patients, which might help explain how the disease develops.
Autoantibodies in rheumatoid arthritis - rheumatoid factor, anticitrullinated protein antibodies and beyond.
Curr Opin Rheumatol
May 2024
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Purpose Of Review: RA is characterized by the presence of autoantibodies among which rheumatoid factors (RFs) and antimodified protein antibodies (AMPA) are serological hallmarks of the disease. In recent years, several novel insights into the biology, immunogenetics and clinical relevance of these autoantibodies have been obtained, which deserve to be discussed in more detail.
Recent Findings: RFs from RA patients seem to target distinct epitopes which appear to be quite specific for RA.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!