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Characterization of the Phenotypic Consequences of the Duffy-Null Genotype.
Blood Adv
January 2025
University of North Carolina at Chapel Hill, CHAPEL HILL, North Carolina, United States.
A wealth of research focused on African American populations has connected rs2814778-CC ("Duffy-null") to decreased neutrophil (neutropenia) and leukocyte counts (leukopenia). While it has been proposed that this variant is benign, prior studies have shown that the misinterpretation of Duffy-null associated neutropenia and leukopenia can lead to unnecessary bone marrow biopsies, inequities in cytotoxic and chemotherapeutic treatment courses, under-enrollment in clinical trials, and other disparities. To investigate the phenotypic correlates of Duffy-null status, we conducted a phenome-wide association study (PheWAS) across more than 1,400 clinical conditions in All of Us, the Vanderbilt University Medical Center's Biobank, and the Million Veteran Program.
View Article and Find Full Text PDFFibromyalgia syndrome-a bodily distress disorder/somatic symptom disorder?
Pain Rep
February 2025
Department Psychosomatic Medicine and Psychotherapy, Technical University Munich, Munich, Germany.
Introduction: The debate addressing the classification of chronic widespread pain as a physical disorder (fibromyalgia syndrome) [FMS] or a somatoform disorder according to psychiatric classification systems has continued for decades.
Objectives: The review aims to line out the new perspectives introduced by the 11th version of the International Classification of Diseases (ICD 11) of the World Health Organization (WHO).
Methods: Critical review of the classification criteria of fibromyalgia syndrome and bodily distress disorder in ICD 11.
Causal language and inferences in observational rotator cuff database studies published from 2013 to 2022.
J Orthop
July 2025
Department of Orthopaedic Surgery, Virginia Commonwealth University, 1250 E. Marshall Street, Richmond, VA, 23219, USA.
Background: The use of large multi-institutional databases in rotator cuff repair (RCR) research is expanding, but these studies are observational and cannot establish causation. This study examines the prevalence of causal language in clinical RCR database studies published from 2013 to 2022.
Methods: Administrative database and clinical registry studies on RCR published in eight orthopaedic journals from 2013 to 2022 were systematically identified and graded by two reviewers for the presence, absence, or inconsistent use of causal language in both the title/abstract and the full text.
Evaluation and Improving the Quality of Arterial Blood Gas Interpretation Among Junior Doctors in Aswan University Hospital: A Clinical Audit.
Cureus
December 2024
Pulmonary Medicine, Aswan University Hospitals, Aswan, EGY.
Article Synopsis
- Arterial blood gas (ABG) analysis is crucial for diagnosing critical conditions in patients, and misinterpretation can lead to serious management issues.
- A study conducted at Aswan University Hospitals involved 273 healthcare professionals and assessed their ABG interpretation skills before and after targeted educational interventions over two weeks.
- Results indicated significant improvements, with accuracy in interpreting ABG results increasing from 71.8% to 90.2% and enhanced skills in identifying acid-base disturbances and distinguishing between respiratory and metabolic issues.
Unveiling the intrinsic role of malnutrition in patients with Crohn's disease undergoing major surgery using weighting analysis.
Br J Nutr
October 2024
Colorectal and General Surgery Unit, Ospedale Santa Maria delle Croci - Ravenna (AUSL Romagna), Ravenna, Italy.
The negative role of malnutrition in patients with Crohn's disease is known; however, many coexisting disease-related factors could cause misinterpretation of the real culprit. This study aimed to describe the role of malnutrition using a novel methodology, This was a retrospective analysis of consecutive patients undergoing elective major surgery for Crohn's disease, preoperatively screened following the European Society for Clinical Nutrition guidelines. Two-step was applied to the group of malnourished patients to obtain an equal cohort having a null or low risk of malnutrition.
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