AI Article Synopsis
- Recent research has shifted focus to the roles of cyclin-dependent kinases 7 and 9 (CDK7 and CDK9) beyond the cell cycle, highlighting their involvement in cell stress response, metabolism of harmful substances, and maintaining internal stability.
- Under stress conditions, the expression of AccCDK7 and AccCDK9 is significantly increased, which is vital for bees’ survival during high temperature challenges.
- Silencing these kinases affects antioxidant gene expression and enzyme activity, while overexpressing them in yeast enhances stress resistance, suggesting a critical role for AccCDK7 and AccCDK9 in honeybee oxidative stress responses.
Article Abstract
Previous studies examining the functions of cyclin-dependent kinases (CDKs) have mainly focused on the regulation of the cell cycle. Recent studies have found that cyclin-dependent kinase 7 (CDK7) and cyclin-dependent kinase 9 (CDK9) play important roles in cell stress, metabolism of toxic substances and maintaining the stability of the internal environment. Here, we found that under stress conditions, the transcription and protein expression of AccCDK7 and AccCDK9 were induced to varying degrees. Meanwhile, the silencing of AccCDK7 and AccCDK9 also affected the expression of antioxidant genes and the activity of antioxidant enzymes, and reduced the survival rate of bees under high temperature stress. Furthermore, the exogenous overexpression of AccCDK7 and AccCDK9 improved the viability of yeast under stress conditions. Therefore, AccCDK7 and AccCDK9 may play roles in A.cerana cerana resistance to oxidative stress caused by external stimuli, potentially revealing a new mechanism of the honeybee response to oxidative stress.
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| http://dx.doi.org/10.1016/j.etap.2023.104117 | DOI Listing |
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Identification of the AccCDK7 and AccCDK9 genes and their involvement in the response to resist external stress in Apis cerana cerana.
Environ Toxicol Pharmacol
June 2023
College of Animal Science and Technology, Shandong Agricultural University, Taian, Shandong 271018, PR China. Electronic address:
Article Synopsis
- Recent research has shifted focus to the roles of cyclin-dependent kinases 7 and 9 (CDK7 and CDK9) beyond the cell cycle, highlighting their involvement in cell stress response, metabolism of harmful substances, and maintaining internal stability.
- Under stress conditions, the expression of AccCDK7 and AccCDK9 is significantly increased, which is vital for bees’ survival during high temperature challenges.
- Silencing these kinases affects antioxidant gene expression and enzyme activity, while overexpressing them in yeast enhances stress resistance, suggesting a critical role for AccCDK7 and AccCDK9 in honeybee oxidative stress responses.
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