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The role of Juniperus Macrocarpa extract as anti-inflammatory and antioxidant on methotrexate-induced acute liver injury in rat model.
F1000Res
March 2025
PhD (Pharmacology), Department of Pharmacology, College of Medicine, University of Baghdad, Baghdad, Baghdad Governorate, Iraq.
Background: Methotrexate (MTX) is an antifolate medication indicated to treat an array of tumors and autoinflammatory maladies. MTX may exhibit harmful impacts on multiple organs, especially liver injury and cirrhosis. Juniperus macrocarpa is a medicinal herb enriched with polyphenols and flavonoids featuring robust anti-inflammatory and antioxidative benefits.
View Article and Find Full Text PDFLncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency.
Drug Des Devel Ther
March 2025
Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, People's Republic of China.
Background: KCNH2 encodes the hERG potassium channel, which is associated with drug-induced long QT syndrome. Arsenic trioxide (ATO) is an effective therapeutic agent for acute promyelocytic leukemia; however, its long-term use can lead to cardiotoxicity, particularly in cases of acquired long QT syndrome (acLQTS), which may result in torsade de pointes (TdP). Therefore, it is essential to comprehend the mechanisms behind acLQTS and to develop effective preventive and therapeutic strategies.
View Article and Find Full Text PDFAcute Generalized Exanthematous Pustulosis in a 76-year-Old Man With Neuroendocrine Carcinoma of the Lung, Responsive to Ixekizumab.
Clin Cosmet Investig Dermatol
February 2025
Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People's Republic of China.
Acute generalized exanthematous pustulosis (AGEP) is a rare, painful, and pruritic drug-induced rash characterized by sterile pustules on an erythematous base, followed by desquamation. While commonly induced by antibiotics, cases associated with antineoplastic drugs have become more frequent in recent years. Here, we report a 76-year-old Chinese male with lung large-cell neuroendocrine carcinoma who developed erythema and pustules on his left lower leg, which spread to the trunk and limbs after the fourth cycle of immunotherapy and chemotherapy.
View Article and Find Full Text PDFA perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury.
Toxicol In Vitro
May 2025
TissUse GmbH, Berlin, Germany. Electronic address:
The kidney is frequently exposed to high levels of drugs and their metabolites, which can injure the kidney and the proximal tubule (PT) in particular. In order to detect nephrotoxicity early during drug development, relevant in vitro models are essential. Here, we introduce a robust and versatile cell culture insert-based iPSC-derived PT model, which can be maintained in a microphysiological system for at least ten days.
View Article and Find Full Text PDFIncidence and risk of drug-induced interstitial lung disease associated with anti-neoplastic drugs.
Expert Opin Drug Saf
March 2025
Department of Biohealth Regulatory Science, Graduate School of Ajou University, Suwon, South Korea.
Background: To evaluate the incidence and risk of drug-induced interstitial lung disease (DIILD) associated with anti-neoplastic drugs among patients with cancer in Korea.
Research Design And Methods: This nested case-control study included 457,685 patients diagnosed with cancer and treated with anti-neoplastic drugs from a retrospective nationwide population-based cohort between 2017 and 2021. The incidence rate of DIILD and the risks of DIILD by anti-neoplastic drug categories were analyzed.
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