Mpox, formerly known as monkeypox, emerged as a viral zoonotic disease in 2022. The World Health Organization (WHO) declared a global pandemic in July 2022. Through the U.S. Food and Drug Administration's emergency use authorization, JYNNEOS became the dominant vaccine for prevention of mpox. California leads the nation in the number of U.S. cases, and the outbreak created opportunities for a nurse practitioner-led pop-up vaccination clinic in Los Angeles County. Interprofessional teamwork with pharmacists and public health officials increased the number of individuals vaccinated. By November, the WHO released operational planning guidelines. Nurse practitioners can use these guidelines in anticipation of the next pandemic.
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