AI Article Synopsis
- Schizophrenia (SZ) and intellectual disability (ID) are linked neurodevelopmental disorders where DNA methylation plays a crucial role in their development.
- A family study was conducted with four monozygotic twin families to analyze genome-wide methylation changes, identifying differentially methylated positions (DMPs) and regions (DMRs) associated with these disorders.
- The study found significant DMPs and DMRs related to specific genes, indicating that changes in DNA methylation could impact neurodevelopment and immune system processes in individuals with SZ and ID.
Article Abstract
Objectives: Schizophrenia (SZ) and intellectual disability (ID) are both included in the continuum of neurodevelopmental disorders (NDDs). DNA methylation is known to be important in the occurrence of NDDs. The family study is conducive to eliminate the effects of relative epigenetic backgrounds, and to screen for differentially methylated positions (DMPs) and regions (DMRs) that are truly associated with NDDs.
Methods: Four monozygotic twin families were recruited, and both twin individuals suffered from NDDs (either SZ, ID, or SZ plus ID). Genome-wide methylation analysis was performed in all samples and each family. DMPs and DMRs between NDD patients and unaffected individuals were identified. Functional and pathway enrichment analyses were performed on the annotated genes.
Results: Two significant DMPs annotated to were found in all samples. In Family One, 1476 DMPs mapped to 880 genes, and 162 DMRs overlapping with 153 unique genes were recognised. Our results suggested that the altered methylation levels of , , , and were associated with the development of SZ and ID. Neurodevelopment and the immune system may participate in the occurrence of SZ and ID.
Conclusions: Our findings suggested that DNA methylation participated in the development of NDDs by affecting neurodevelopment and the immune system.
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| http://dx.doi.org/10.1080/15622975.2023.2198595 | DOI Listing |
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