AI Article Synopsis
- The study looked at a new treatment plan for babies in the NICU who have seizures, using a special protocol with three levels.
- They checked how babies did before and after this plan was used over a 25-month period.
- The results showed that while some medications were used less and EEG tests were done for fewer days, the hospital stays didn't change, and more studies are needed to see how this affects babies in the long run.
Article Abstract
Objective: To evaluate use of a standardized, 3-tiered, seizure burden-based protocol for treatment of all electroencephalography (EEG)-confirmed seizures in a level IV neonatal intensive care unit (NICU).
Study Design: All infants admitted to the NICU with EEG-confirmed seizures over a 25-month period were enrolled in the study. We compared short-term outcomes before and after implementation of a standardized, 3-tiered protocol.
Results: A total of 107 infants were enrolled in the study. Use of midazolam infusions was reduced by 53.7% (= 0.02). Midazolam infusion duration increased from 4 to 7.5 days ( = 0.003); however, when excluding 3 outliers, there was no significant difference between groups (-= 0.67). Duration of EEG monitoring decreased from 5 to 3 days (= 0.005). Hospital length of stay was unchanged.
Conclusion: Implementation of a standardized, 3-tiered protocol for treatment of neonatal seizures improved short-term outcomes. Although not measured directly, reductions in EEG duration and midazolam use are promising indicators of overall seizure burden. More research is needed to evaluate impact on long-term neurodevelopmental outcomes.
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| http://dx.doi.org/10.1177/08830738231164704 | DOI Listing |
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