AI Article Synopsis
- Immune-mediated glomerulonephritis with a membranous pattern and masked IgG-Kappa deposits (MGMID) is not well understood, especially regarding the nature of its deposits.
- A case study of a 33-year-old woman showed continuous proteinuria and high levels of SSA antibodies, leading to a kidney biopsy that revealed characteristics of MGMID.
- The study provides the first immunohistochemical evidence of Ro52 positivity in kidney tissues, which may contribute to a better understanding of this condition and its association with autoimmune disorders.
Article Abstract
Background: The nature of the deposits in immune-mediated glomerulonephritis with a membranous pattern and masked IgG-Kappa deposits (MGMID) remains still to be elucidated.
Case Presentation: We present a case of 33-year-old woman developing a continuous asymptomatic proteinuria (0.8-1 g/24 h) with no overt connective tissue diseases. She tested positive at high titers for SSA antibodies (Ro52 838 UI/mL, Ro60 2716 UI/mL) and at the kidney biopsy histological findings were compatible with an immune-mediated glomerulonephritis with a membranous pattern and masked IgG-Kappa deposits. Also, we demonstrated a positive immunohistochemistry staining for anti-Ro52-SSA antibodies, with a granular positivity in mesangium and along rare glomerular capillaries. To date, only one case of a patient with overt diagnosis of Sjögren's syndrome with MGMID has been described but a pathogenic role for SSA and SSB antibodies has never been proven.
Conclusions: In this case, we described for the first time by immunohistochemistry a Ro52+ granular positivity in the mesangium and glomerular capillaries, potentially paving the way for a better understanding of MGMID.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074652 | PMC |
| http://dx.doi.org/10.1186/s41927-023-00330-1 | DOI Listing |
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