AI Article Synopsis

  • Respiratory viruses like RSV contribute significantly to health issues globally, and entry inhibitors show promise as antiviral treatments that could block these viruses in the respiratory tract.
  • A new entry inhibitor, CD-MUS, has been developed that can inactivate various viruses by binding to their attachment proteins, and initial tests on mice show it's well-tolerated.
  • The research has led to the creation of an inhalable powder formulation of CD-MUS, which maintains its effectiveness against RSV and is set for further testing in live animal models.

Article Abstract

Respiratory viruses including the respiratory syncytial virus (RSV) aggravate the global burden of virus-inflicted morbidity and mortality. Entry inhibitors are a promising class of antiviral drugs for combating these viruses, as they can prevent infection at the site of viral entry, i.e., the respiratory tract. Here we used a broad-spectrum entry inhibitor, composed of a β-cyclodextrin backbone, functionalized with 11-mercapto-1-undecanesulfonate (CD-MUS) that is capable of neutralizing a variety of viruses that employ heparan sulfate proteoglycans (HSPG) to infect host cells. CD-MUS inactivates viral particles irreversibly by binding to viral attachment proteins through a multivalent binding mechanism. In the present study, we show that CD-MUS is well tolerated when administered to the respiratory tract of mice. Based on this, we developed an inhalable spray-dried powder formulation that fits the size requirements for lung deposition and disperses well upon use with the Cyclops dry powder inhaler (DPI). Using an in vitro dose-response assay, we show that the compound retained its activity against RSV after the spray drying process. Our study sets the stage for further in vivo studies, exploring the efficacy of pulmonary administered CD-MUS in animal models of RSV infection.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2023.03.059DOI Listing

Publication Analysis

Top Keywords

powder formulation
8
respiratory syncytial
8
syncytial virus
8
respiratory tract
8
respiratory
5
development inhalable
4
inhalable antiviral
4
antiviral powder
4
formulation respiratory
4
virus respiratory
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!