A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This step typically affords a mixture of products, which requires extensive purification to obtain any pure products. We report the development of two continuous-flow protocols for the preparation of (-)--Δ-tetrahydrocannabinol and (-)--Δ-tetrahydrocannabinol.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167683 | PMC |
| http://dx.doi.org/10.1021/acs.joc.3c00300 | DOI Listing |
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