Ameloblastic Fibrodentinoma and Ameloblastic Fibro-Odontoma: A Developing Odontoma or a Distinct Neoplasm?

Int J Surg Pathol

Programa de Pós Graduação em Ciências Odontológicas, Universidade Federal do Espírito Santo, Vitória, Brazil.

Published: December 2023

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http://dx.doi.org/10.1177/10668969231157778DOI Listing

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Ameloblastic fibroma (AF) and related lesions, namely ameloblastic fibrodentinoma (AFD) and ameloblastic fibro-odontoma (AFO), span a spectrum from true neoplasms to hamartomas. The 2017 World Health Organization classification proposes that AFD and AFO are precursors to odontomas, yet their precise nature remains uncertain. This study examined 19 AF cases, 4 AFD, 15 AFO, 19 odontomas (OD, 14 complex, 5 compound), and 2 ameloblastic fibrosarcomas (AFS), focusing on clinical characteristics, recurrence, and molecular profiles.

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Article Synopsis
  • Ameloblastic fibrodentinoma (AFD) is a rare, benign tumor related to teeth, notable for having features similar to ameloblastic fibroma but with abnormal dentin.
  • A case study of a young patient showed AFD in the lower jaw, identified through imaging techniques that revealed a well-defined lesion affecting nearby molars and causing changes in the bone structure.
  • After surgical removal and tooth extraction, no recurrence was detected during a 5-year follow-up, highlighting the importance of recognizing AFD in young patients with certain dental imaging characteristics.
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Article Synopsis
  • Odontomas are growths found in the jaw and are one of the most common types of dental tumors, split into two types: compound and complex.
  • They usually don't cause pain but can affect nearby teeth by getting in the way or causing growth problems.
  • In a study of 242 patients from 2013 to 2022, most cases were found in teens, with compound odontomas being the most common type, often located in the front part of the jaw.
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Background: Ameloblastic fibro-dentinoma is considered a rare, benign, mixed odontogenic tumor that occurs mainly in the posterior mandible in the 1st-2nd decade of life. Although the clinical behavior of Ameloblastic fibro-dentinoma is similar to that of ameloblastic fibroma, there is a debate about whether Ameloblastic fibro-dentinoma is a developing hamartomatous odontoma or a separate neoplastic odontogenic tumor like ameloblastic fibroma. However, it is important to understand the histopathogenesis of this rare tumor.

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