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http://dx.doi.org/10.1016/j.psj.2023.102644 | DOI Listing |
Blood Coagul Fibrinolysis
December 2023
School of Public Health, University of Colorado Denver, Aurora, Colorado, USA.
Introduction: Venous thromboembolism (VTE) remains a significant source of postinjury morbidity and mortality. Beta-hydroxy beta-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (rosuvastatin) significantly reduced pathologic clotting events in healthy populations in a prior trial. Furthermore, acetylsalicylic acid (ASA) has been shown to be noninferior to prophylactic heparinoids for VTE prevention following orthopedic surgery.
View Article and Find Full Text PDFJAMA Surg
December 2023
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Importance: Oral tamoxifen citrate benefits women with ductal carcinoma in situ (DCIS), but concern about toxic effects has limited acceptance. Previous pilot studies have suggested transdermal 4-hydroxytamoxifen gel has equivalent antiproliferative efficacy to oral tamoxifen, with low systemic exposure.
Objective: To demonstrate that 4-hydroxytamoxifen gel applied to the breast skin is noninferior to oral tamoxifen in its antiproliferative effect in DCIS lesions.
Poult Sci
July 2023
Adisseo France SAS, 03600 Malicorne, France.
Poult Sci
July 2023
Bioinformatics Unit, University of Hohenheim, 70593 Stuttgart, Germany.
Vaccine
April 2023
MSD (UK) Limited, London, United Kingdom.
Background: This phase III study evaluated safety, tolerability, and immunogenicity of V114 (15-valent pneumococcal conjugate vaccine) in healthy infants. V114 contains all 13 serotypes in PCV13 and additional serotypes 22F and 33F.
Methods: Healthy infants were randomized to two primary doses and one toddler dose (2+1 regimen) of V114 or PCV13 at 3, 5, and 12 months of age; diphtheria, tetanus, pertussis (DTaP), inactivated poliovirus (IPV), Haemophilus influenzae type b (Hib), hepatitis B (HepB) vaccine was administered concomitantly.
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