AI Article Synopsis
- Antibiotic-resistant bacterial infections are a major global health issue, with existing treatments becoming less effective and the antibiotic development pipeline running dry.
- Natural macrocyclic peptides have shown promise as new antibiotics, but finding and developing these products is currently a slow process.
- Synthetic peptide display technologies offer a faster alternative to screen large libraries for effective new antibiotics, emphasizing the need for innovative strategies in drug discovery.
Article Abstract
Antibiotic resistant bacterial infections are now a leading cause of global mortality. While drug resistance continues to spread, the clinical antibiotic pipeline has become bare. This discord has focused attention on developing new strategies for antimicrobial discovery. Natural macrocyclic peptide-based products have provided novel antibiotics and antibiotic scaffolds targeting several essential bacterial cell envelope processes, but discovery of such natural products remains a slow and inefficient process. Synthetic strategies employing peptide display technologies can quickly screen large libraries of macrocyclic sequences for specific target binding and general antibacterial potential providing alternative approaches for new antibiotic discovery. Here we review cell envelope processes that can be targeted with macrocyclic peptide therapeutics, outline important macrocyclic peptide display technologies, and discuss future strategies for both library design and screening.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198949 | PMC |
| http://dx.doi.org/10.1016/j.bbamcr.2023.119473 | DOI Listing |
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