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The continually evolving landscape of novel therapies in oncogene-driven advanced non-small-cell lung cancer.
Ther Adv Med Oncol
January 2025
Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
Non-small-cell lung cancer (NSCLC) is a highly heterogeneous disease that is frequently associated with a host of known oncogenic alterations. Advances in molecular diagnostics and drug development have facilitated the targeting of novel alterations such that the majority of NSCLC patients have driver mutations that are now clinically actionable. The goal of this review is to gain insights into clinical research and development principles by summary, analysis, and discussion of data on agents targeting known alterations in oncogene-driven, advanced NSCLC beyond those in the and the .
View Article and Find Full Text PDFTalking Cancer-Cancer Talking: A Linguistic and Thematic Analysis of Patient Narratives.
J Patient Exp
December 2024
Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.
To explore "the lived experience" of patients with cancer through narratives, in-depth interviews with 20 patients were conducted in the patients' homes-"at the kitchen table." Interviews were audio-recorded, transcribed, and analyzed following the Linguistic Inquiry and Word Count (LIWC) methodology. Thematic Analysis was used to explore themes in the narratives.
View Article and Find Full Text PDFEffects of Phenolic Compounds on Biofilm Formation by Table Olive-Related Microorganisms.
Food Sci Nutr
December 2024
Food Biotechnology Department, Instituto de la Grasa (CSIC) Campus Universitario Pablo de Olavide Seville Spain.
The process of biofilm formation during table olive fermentation is crucial to turning this fermented vegetable into a probiotic food. Some phenolic compounds have been described as important quorum-sensing molecules during biofilm development. The present in vitro study examined the effects of three phenolic compounds widely found in table olive fermentations (Oleuropein 0-3000 ppm, Hydroxytyrosol 0-3000 ppm, and Tyrosol 0-300 ppm) on the development of single biofilm by diverse microorganisms isolated from table olives ( 13B4, Lp119, and LPG1; Lp15 and LAB23; and yeasts Y12, Y13, and Y18).
View Article and Find Full Text PDFMaximizing Aesthetic Outcomes in Delayed Breast Reconstruction: the Be.A.U.T-I.F.U.L. DIEP Step-by-Step Inset Technique.
Aesthetic Plast Surg
December 2024
Department of Plastic and Hand Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne (UNIL), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Introduction: In microvascular breast reconstruction, the focus has shifted to achieving aesthetically pleasing results. Delayed breast reconstruction poses challenges such as ensuring natural ptosis and avoiding a "patch" effect. The Be.
View Article and Find Full Text PDFThis paper draws on notions of embodied learning to inform exhibit design that fosters children's meaningful embodied engagement to successfully unveil science ideas. While children's interaction in the museum is often hands-on and speaks to the physical emphasis that embodiment brings, observation of children's spontaneous engagement at a museum's Water Zone revealed opportunities and barriers to engagement with, and access to, science ideas in terms of what we call 'embodied proximity' and 'embodied dislocation'. Drawing on design considerations from these findings a set of purpose-built prototype exhibits were developed and deployed to examine how they supported children's embodied exploration of science.
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