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Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception.
medRxiv
December 2024
African Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.
Adversity in childhood is robustly associated with persistent pain in adulthood. Neuro-immune interactions are a candidate mechanistic link between childhood adversity and persistent pain, given that both childhood adversity and persistent pain are associated with neural and immune upregulation in adulthood. As such, we aimed to clarify whether immune reactivity is associated with provoked differences in nociceptive processing in humans.
View Article and Find Full Text PDFRegulation of important natural products biosynthesis by WRKY transcription factors in plants.
J Adv Res
January 2025
Department of Chinese Medicine Authentication, College of Pharmacy, Naval Medical University, No.325 Guohe Road, Shanghai 200433, China; Department of Pharmacy, Shanghai Fourth People's Hospital Affiliated to Tongji University, No.1279 Sanmen Road, Shanghai 200434, China; Shanghai Key Laboratory for Pharmaceutical Metabolite Research, No.325 Guohe Road, Shanghai 200433, China. Electronic address:
Background: Plants produce abundant natural products, among which are species-specific and diversified secondary metabolites that are essential for growth and development, as well as adaptation to adversity and ecology. Moreover, these secondary metabolites are extensively utilized in pharmaceuticals, fragrances, industrial materials, and more. WRKY transcription factors (TFs), as a family of TFs unique to plants, have significant functions in many plant life activities.
View Article and Find Full Text PDFThe Health-Related Quality of Life Impact of the COVID-19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ-5D-5L with Psychosocial Bolt-Ons.
Brain Behav
January 2025
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Objectives: Studies have shown that people living with multiple sclerosis (PwMS) were substantially impacted by the COVID-19 pandemic. However, no study has compared the overall health-related quality of life impact of the COVID-19 pandemic on PwMS and the general population. Differences would have implications for crises/pandemic management policies.
View Article and Find Full Text PDFDepression in the COVID-19 endemic era: Analysis of online self-disclosures by young South Koreans.
PLoS One
December 2024
Department of Psychology, Yonsei University, Seoul, Republic of Korea.
Although COVID-19 has been declared endemic in South Korea, there are economic and psychosocial after-effects. One of these is the prevalence of depression. Depressed adolescents and young adults struggle with insecurity, loneliness, and lack of confidence due to the life limitations imposed during the pandemic.
View Article and Find Full Text PDFClinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT.
Public Health Res (Southampt)
December 2024
Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Background: Problems in children's early social and emotional development are likely to have major long-term consequences for the individual and society: maternal emotional well-being is associated with better outcomes. Interventions designed to improve both maternal mental health and the mother-child relationship are thus likely to benefit both maternal health and child development.
Objectives: To establish the clinical and cost-effectiveness of the Mellow Babies parenting intervention for women experiencing psychosocial stress and their 6- to 18-month-old babies.
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