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Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies. | LitMetric
Synthesis of novel pyran-based uracils that may have potent antitumor activity against hepatocellular carcinoma HepG2 and ovarian cancer SKOV3 cell lines. Novel pyran-based uracils were synthesized and their anticancer activity was assessed using methyl thiazolyl tetrazolium and wound-healing assays to detect their cytotoxicity and their antiproliferative and antimigratory activities. Compounds , , , , , , , and significantly inhibited cell proliferation of the HepG2 cell line. Compounds , , and significantly inhibited the proliferation of SKOV3 cells, which was also proven through docking studies with topoisomerase I. The molecular docking analysis revealed that and are two major compounds found to possess higher degrees of interaction with DNA gyrase.
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