AI Article Synopsis
- - A range of piperidines and pyrrolidines with CF and CHF groups were successfully synthesized using visible light photocatalysis with CFSONa and CHFSONa.
- - The process employs a radical cascade that allows for multiple reactions, including tri- and difluoromethylation as well as arylation of unactivated alkenes.
- - This method highlights its advantages such as mild conditions and the absence of additives and transition metals, while also increasing the variety of possible chemical structures derived from compounds like benzimidazole and indole.
Article Abstract
A variety of azaheterocycle-fused piperidines and pyrrolidines bearing CF and CHF functionalities were obtained using CFSONa and CHFSONa by visible light photocatalysis. This protocol involves a radical cascade cyclization tandem tri- and difluoromethylation-arylation of pendent unactivated alkenes. Benzimidazole, imidazole, theophylline, purine, and indole serve as applicable anchors, thereby enriching the structural diversity of piperidine and pyrrolidine derivatives. This method features mild, additive-free and transition metal-free conditions.
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| http://dx.doi.org/10.1039/d3ob00241a | DOI Listing |
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